What compounds affect the RIP-mediated NFkB activation via ZBP1 pathway?

50 compounds in the BiohacksAI corpus have documented interactions with genes in the RIP-mediated NFkB activation via ZBP1 pathway (Reactome ID: R-HSA-1810476). These compounds target 8 genes within this pathway.

What genes are in the RIP-mediated NFkB activation via ZBP1 pathway?

The RIP-mediated NFkB activation via ZBP1 pathway involves 8 genes. Key genes include: CHUK, IKBKB, NFKB1, NFKB2, NFKBIA, RELA, RIPK3, TLR3.

RIP-mediated NFkB activation via ZBP1

REACTOME PATHWAY

Reactome: R-HSA-18104768 genes50 compounds

The RIP-mediated NFkB activation via ZBP1 pathway (Reactome ID: R-HSA-1810476) involves 8 genes and is affected by 50 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHUK IKBKB NFKB1 NFKB2 NFKBIA RELA RIPK3 TLR3

Compounds Affecting RIP-mediated NFkB activation via ZBP1

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Quercetin	—	300
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Podophyllotoxin	—	14
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Rutin	—	300
10	Withania	—	500
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	tamarixetin	—	26
13	withaferin	—	300
14	Trifluridine	—	295
15	vinblastine sulfate	—	81
16	Hydrocortisone	—	299
17	egcg	—	300
18	Cerulenin	—	300
19	Chlorpropamide	—	300
20	daph	—	2
21	Disulfiram	—	297
22	Hexachlorophene	—	300
23	Hydrocortisone	—	298
24	Lovastatin	—	300
25	ly294002	—	11
26	Promethazine	—	121
27	protriptyline	—	296
28	streptonigrin	—	299
29	Sulfaphenazole	—	300
30	Triamcinolone	—	300
31	tyrphostin 1	—	1
32	tyrphostin ag 1478	—	4
33	Voriconazole	—	299
34	Cathelicidins Antimicrobial cationic peptides with	—	300
35	plumbagin [Supplementary Concept]	—	300
36	Ursolic Acid	—	300
37	Oleanolic Acid	—	300
38	pyrrolidine dithiocarbamate	—	275
39	Budesonide	—	1,000
40	Dibucaine	—	299
41	Dimethylphenylpiperazinium Iodide	—	33
42	Edaravone	—	298
43	Fluocinolone Acetonide	—	295
44	Sulfadimethoxine	—	300
45	alsterpaullone	—	12
46	Aurintricarboxylic Acid	—	184
47	Crizotinib	—	298
48	sp600125	—	117
49	glaucarubinone	—	10
50	Vemurafenib	—	298

About the RIP-mediated NFkB activation via ZBP1 Pathway

The RIP-mediated NFkB activation via ZBP1 pathway is catalogued in Reactome (ID: R-HSA-1810476) and involves 8 genes. In the BiohacksAI corpus, 50 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB, NFKB1, NFKB2, NFKBIA.