What compounds affect the Signalling to ERKs pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Signalling to ERKs pathway (Reactome ID: R-HSA-187687). These compounds target 14 genes within this pathway.

What genes are in the Signalling to ERKs pathway?

The Signalling to ERKs pathway involves 14 genes. Key genes include: BRAF, GRB2, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3.

Signalling to ERKs

REACTOME PATHWAY

Reactome: R-HSA-18768714 genes40 compounds

The Signalling to ERKs pathway (Reactome ID: R-HSA-187687) involves 14 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF GRB2 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 NTRK1 SRC YWHAB

Compounds Affecting Signalling to ERKs

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
3	withaferin	—	300
4	Dasatinib	—	299
5	pd98059	—	7
6	trametinib	—	296
7	Afatinib	—	297
8	Quercetin	—	300
9	Anisomycin	—	247
10	tyrphostin ag 1478	—	4
11	alsterpaullone	—	12
12	kenpaullone	—	8
13	sp600125	—	117
14	Axitinib	—	298
15	Vemurafenib	—	298
16	plumbagin [Supplementary Concept]	—	300
17	fisetin	—	78
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Crizotinib	—	298
20	Clotrimazole	—	296
21	Progesterone	—	299
22	2-Chloroadenosine 2-Chloroadenosine.	—	300
23	Benzalkonium Compounds	—	299
24	Calcimycin	—	216
25	daph	—	2
26	Diphenhydramine	—	14
27	ha1004	—	4
28	Lithocholic Acid	—	300
29	Loratadine	—	296
30	trequinsin hydrochloride	—	1
31	egcg	—	300
32	Celecoxib	—	295
33	Resveratrol	—	298
34	Adenosine Monophosphate Adenine nucleotide containing	—	300
35	monorden	—	8
36	Niclosamide	—	299
37	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
38	pictilisib	—	25
39	Adenosine Triphosphate	—	300
40	Dactinomycin	—	297

About the Signalling to ERKs Pathway

The Signalling to ERKs pathway is catalogued in Reactome (ID: R-HSA-187687) and involves 14 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, GRB2, MAP2K1, MAP2K2, MAPK1.