What compounds affect the Signaling by FGFR pathway?

57 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FGFR pathway (Reactome ID: R-HSA-190236). These compounds target 16 genes within this pathway.

What genes are in the Signaling by FGFR pathway?

The Signaling by FGFR pathway involves 16 genes. Key genes include: BRAF, FGF22, FGFR1, FGFR2, FGFR3, FGFR4, GALNT3, GRB2, HNRNPA1, MAPK1.

Signaling by FGFR

REACTOME PATHWAY

Reactome: R-HSA-19023616 genes57 compounds

The Signaling by FGFR pathway (Reactome ID: R-HSA-190236) involves 16 genes and is affected by 57 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGF22 FGFR1 FGFR2 FGFR3 FGFR4 GALNT3 GRB2 HNRNPA1 MAPK1 MAPK3 MKNK1 PIK3R1 PPP2CA PTBP1 SRC

Compounds Affecting Signaling by FGFR

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	alsterpaullone	—	12
4	Quercetin	—	300
5	tyrphostin ag 1478	—	4
6	kenpaullone	—	8
7	sp600125	—	117
8	Axitinib	—	298
9	plumbagin [Supplementary Concept]	—	300
10	pd98059	—	7
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	trametinib	—	296
13	withaferin	—	300
14	Afatinib	—	297
15	Crizotinib	—	298
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Clotrimazole	—	296
18	fisetin	—	78
19	Progesterone	—	299
20	2-Chloroadenosine 2-Chloroadenosine.	—	300
21	Benzalkonium Compounds	—	299
22	Calcimycin	—	216
23	daph	—	2
24	Diphenhydramine	—	14
25	ha1004	—	4
26	Lithocholic Acid	—	300
27	Loratadine	—	296
28	trequinsin hydrochloride	—	1
29	Resveratrol	—	298
30	Adenosine Monophosphate Adenine nucleotide containing	—	300
31	monorden	—	8
32	Niclosamide	—	299
33	Azauridine	—	300
34	Carboxin	—	174
35	Digitoxin	—	300
36	Digoxin	—	299
37	Ethylenethiourea	—	300
38	Nadolol	—	297
39	Ouabain	—	300
40	streptonigrin	—	299
41	Sulfadiazine	—	298
42	Thioridazine	—	35
43	triflupromazine hydrochloride	—	12
44	pictilisib	—	25
45	Wortmannin	—	300
46	ly294002	—	11
47	alpelisib	—	227
48	Sirolimus	—	300
49	torin 1	—	10
50	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150

About the Signaling by FGFR Pathway

The Signaling by FGFR pathway is catalogued in Reactome (ID: R-HSA-190236) and involves 16 genes. In the BiohacksAI corpus, 57 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGF22, FGFR1, FGFR2, FGFR3.