What genes are in the Pre-NOTCH Transcription and Translation pathway?

The Pre-NOTCH Transcription and Translation pathway involves 10 genes. Key genes include: AGO2, CREBBP, ELANE, EP300, JUN, KAT2A, KAT2B, RUNX1, SIRT6, TP53.

Pre-NOTCH Transcription and Translation

Q: What compounds affect the Pre-NOTCH Transcription and Translation pathway?

219 compounds in the BiohacksAI corpus have documented interactions with genes in the Pre-NOTCH Transcription and Translation pathway (Reactome ID: R-HSA-1912408). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-191240810 genes219 compounds

The Pre-NOTCH Transcription and Translation pathway (Reactome ID: R-HSA-1912408) involves 10 genes and is affected by 219 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 CREBBP ELANE EP300 JUN KAT2A KAT2B RUNX1 SIRT6 TP53

Compounds Affecting Pre-NOTCH Transcription and Translation

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	plumbagin [Supplementary Concept]	—	300
3	Nocodazole Nocodazole is	—	215
4	Colchicine	—	300
5	egcg	—	300
6	Ethidium	—	300
7	Hexachlorophene	—	300
8	Methylene Blue	—	200
9	Bortezomib	—	300
10	Rotenone	—	300
11	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
12	Daunorubicin	—	298
13	Vitamin K 3	—	300
14	Quercetin	—	300
15	ninhydrin	—	300
16	Estramustine	—	300
17	Clotrimazole	—	296
18	Methylnitronitrosoguanidine	—	52
19	Thioridazine	—	35
20	vinblastine sulfate	—	81
21	Clofibrate	—	299
22	Fenofibrate	—	297
23	Harmaline	—	300
24	Iodoacetamide	—	300
25	Nisoldipine	—	297
26	Oxyphenbutazone	—	300
27	rafoxanide	—	172
28	triflupromazine hydrochloride	—	12
29	Vincristine	—	299
30	Sertraline	—	1,000
31	alpha-Linolenic Acid	—	300
32	Amoxapine	—	259
33	Chlormadinone Acetate	—	300
34	Cinnarizine	—	299
35	diallyl trisulfide	—	246
36	ethopropazine hydrochloride	—	2
37	Ethynodiol Diacetate	—	300
38	Maprotiline	—	299
39	Robenidine	—	162
40	Salmeterol Xinafoate	—	227
41	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
42	DEAD-box RNA Helicases	—	169
43	Thioctic Acid	—	298
44	Thioctic Acid	—	300
45	Lithocholic Acid	—	300
46	Aurintricarboxylic Acid	—	184
47	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
48	Ethinyl Estradiol	—	300
49	Azacitidine	—	298
50	Azacitidine	—	300

About the Pre-NOTCH Transcription and Translation Pathway

The Pre-NOTCH Transcription and Translation pathway is catalogued in Reactome (ID: R-HSA-1912408) and involves 10 genes. In the BiohacksAI corpus, 219 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, CREBBP, ELANE, EP300, JUN.