What compounds affect the p75NTR signals via NF-kB pathway?

50 compounds in the BiohacksAI corpus have documented interactions with genes in the p75NTR signals via NF-kB pathway (Reactome ID: R-HSA-193639). These compounds target 6 genes within this pathway.

What genes are in the p75NTR signals via NF-kB pathway?

The p75NTR signals via NF-kB pathway involves 6 genes. Key genes include: IKBKB, IRAK1, NFKB1, NFKBIA, RELA, RIPK2.

p75NTR signals via NF-kB

REACTOME PATHWAY

Reactome: R-HSA-1936396 genes50 compounds

The p75NTR signals via NF-kB pathway (Reactome ID: R-HSA-193639) involves 6 genes and is affected by 50 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IKBKB IRAK1 NFKB1 NFKBIA RELA RIPK2

Compounds Affecting p75NTR signals via NF-kB

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Crizotinib	—	298
3	Quercetin	—	300
4	Resveratrol	—	298
5	Bortezomib	—	300
6	Podophyllotoxin	—	14
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Kaempferols	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Rutin	—	300
11	Withania	—	500
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	tamarixetin	—	26
14	Trifluridine	—	295
15	withaferin	—	300
16	Sorafenib	—	300
17	Afatinib	—	297
18	Axitinib	—	298
19	alsterpaullone	—	12
20	Hydrocortisone	—	299
21	egcg	—	300
22	Cerulenin	—	300
23	Chlorpropamide	—	300
24	daph	—	2
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Hydrocortisone	—	298
28	Lovastatin	—	300
29	ly294002	—	11
30	Promethazine	—	121
31	protriptyline	—	296
32	streptonigrin	—	299
33	Sulfaphenazole	—	300
34	Triamcinolone	—	300
35	tyrphostin 1	—	1
36	tyrphostin ag 1478	—	4
37	Voriconazole	—	299
38	Cathelicidins Antimicrobial cationic peptides with	—	300
39	plumbagin [Supplementary Concept]	—	300
40	Ursolic Acid	—	300
41	Oleanolic Acid	—	300
42	pyrrolidine dithiocarbamate	—	275
43	vinblastine sulfate	—	81
44	Oxyphenbutazone	—	300
45	Anisomycin	—	247
46	cycloheximide	—	300
47	Dasatinib	—	299
48	Vemurafenib	—	298
49	Aurintricarboxylic Acid	—	184
50	sp600125	—	117

About the p75NTR signals via NF-kB Pathway

The p75NTR signals via NF-kB pathway is catalogued in Reactome (ID: R-HSA-193639) and involves 6 genes. In the BiohacksAI corpus, 50 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IKBKB, IRAK1, NFKB1, NFKBIA, RELA.