What compounds affect the Glucocorticoid biosynthesis pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Glucocorticoid biosynthesis pathway (Reactome ID: R-HSA-194002). These compounds target 5 genes within this pathway.

What genes are in the Glucocorticoid biosynthesis pathway?

The Glucocorticoid biosynthesis pathway involves 5 genes. Key genes include: CYP11B1, CYP11B2, CYP17A1, HSD11B1, SERPINA6.

Glucocorticoid biosynthesis

REACTOME PATHWAY

Reactome: R-HSA-1940025 genes34 compounds

The Glucocorticoid biosynthesis pathway (Reactome ID: R-HSA-194002) involves 5 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP11B1 CYP11B2 CYP17A1 HSD11B1 SERPINA6

Compounds Affecting Glucocorticoid biosynthesis

#	Compound	Targets Hit	Studies
1	Fadrozole	—	300
2	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
3	Letrozole	—	298
4	Corticosterone	—	300
5	Hydrocortisone	—	299
6	Dehydroepiandrosterone	—	300
7	Prednisolone	—	1,000
8	Progesterone	—	299
9	Testosterone	—	299
10	17-alpha-Hydroxyprogesterone	—	300
11	Aldosterone	—	300
12	Algestone	—	35
13	Androstenediol	—	300
14	Androstenedione	—	300
15	Androsterone	—	300
16	Cortisone	—	299
17	Dehydroepiandrosterone	—	300
18	Desoxycorticosterone	—	300
19	Dihydrotestosterone	—	300
20	Estriol	—	300
21	Estrone	—	300
22	Etiocholanolone	—	300
23	Hydrocortisone	—	298
24	Cervugid [Supplementary Concept]	—	300
25	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
26	Pregnenolone	—	300
27	Abiraterone Acetate	—	296
28	Clotrimazole	—	296
29	Econazole	—	299
30	Miconazole	—	298
31	Testosterone Propionate	—	300
32	Ursolic Acid	—	300
33	Furosemide	—	298
34	Bilirubin	—	296

About the Glucocorticoid biosynthesis Pathway

The Glucocorticoid biosynthesis pathway is catalogued in Reactome (ID: R-HSA-194002) and involves 5 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP11B1, CYP11B2, CYP17A1, HSD11B1, SERPINA6.