What compounds affect the Signaling by WNT pathway?

80 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by WNT pathway (Reactome ID: R-HSA-195721). These compounds target 66 genes within this pathway.

What genes are in the Signaling by WNT pathway?

The Signaling by WNT pathway involves 66 genes. Key genes include: ADRM1, AGO2, ASH2L, CREBBP, CSNK1A1, CSNK1E, CSNK1G2, CSNK2A1, CSNK2A2, CSNK2B.

Signaling by WNT

REACTOME PATHWAY

Reactome: R-HSA-19572166 genes80 compounds

The Signaling by WNT pathway (Reactome ID: R-HSA-195721) involves 66 genes and is affected by 80 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 ASH2L CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CUL1 DPY30 EP300 FZD1 GNAO1 GSK3B HDAC1 MAP3K7 MEN1 MYC NLK PDE6A PLCB3 PPP2CA PPP2R5A PSMA1 PSMA2 PSMA3 PSMA4+36 more

Compounds Affecting Signaling by WNT

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	egcg	—	300
7	chrysin	—	300
8	sp600125	—	117
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	Kaempferols	—	300
11	fisetin	—	78
12	ly294002	—	11
13	Sorafenib	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	s adenosylhomocysteine	—	300
16	alsterpaullone	—	12
17	Vanillic Acid	—	300
18	pictilisib	—	25
19	kenpaullone	—	8
20	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
21	Ursolic Acid	—	300
22	Dasatinib	—	299
23	celastrol	—	300
24	plumbagin [Supplementary Concept]	—	300
25	ninhydrin	—	300
26	Okadaic Acid	—	300
27	indirubin	—	300
28	Lithium Chloride	—	300
29	Rutin	—	300
30	Oleanolic Acid	—	300
31	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
32	Dichlororibofuranosylbenzimidazole	—	26
33	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
34	Axitinib	—	298
35	Disulfiram	—	297
36	4-Hydroxybenzoate-3-Monooxygenase	—	300
37	Genistein	—	300
38	Vorinostat	—	299
39	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
40	scriptaid	—	53
41	Valproic Acid	—	296
42	Butyric Acid	—	300
43	Celecoxib	—	295
44	Daunorubicin	—	298
45	Camptothecin	—	300
46	Afatinib	—	297
47	Adapalene	—	296
48	alpha-Linolenic Acid	—	300
49	prunetin	—	35
50	NAD	—	300

About the Signaling by WNT Pathway

The Signaling by WNT pathway is catalogued in Reactome (ID: R-HSA-195721) and involves 66 genes. In the BiohacksAI corpus, 80 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, ASH2L, CREBBP, CSNK1A1.