What compounds affect the CREB phosphorylation pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the CREB phosphorylation pathway (Reactome ID: R-HSA-199920). These compounds target 6 genes within this pathway.

What genes are in the CREB phosphorylation pathway?

The CREB phosphorylation pathway involves 6 genes. Key genes include: CREB1, MAPKAPK2, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA5.

CREB phosphorylation

REACTOME PATHWAY

Reactome: R-HSA-1999206 genes52 compounds

The CREB phosphorylation pathway (Reactome ID: R-HSA-199920) involves 6 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 MAPKAPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5

Compounds Affecting CREB phosphorylation

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	fisetin	—	78
3	sp600125	—	117
4	cycloheximide	—	300
5	Disulfiram	—	297
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Levalbuterol	—	1,000
10	Adenosine Monophosphate Adenine nucleotide containing	—	300
11	Levalbuterol	—	297
12	Bortezomib	—	300
13	Clofarabine	—	298
14	Dactinomycin	—	297
15	Danazol	—	298
16	Emetine	—	298
17	Ethidium	—	300
18	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
19	Sulbactam	—	299
20	trequinsin hydrochloride	—	1
21	chrysin	—	300
22	Genistein	—	300
23	Quercetin	—	300
24	Testosterone	—	299
25	Ciclopirox	—	88
26	Cladribine	—	297
27	Clenbuterol	—	300
28	Corticosterone	—	300
29	Dasatinib	—	299
30	Daunorubicin	—	298
31	Dinoprostone	—	296
32	Epinephrine	—	299
33	Ethinyl Estradiol	—	300
34	Imatinib Mesylate	—	300
35	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
36	Nisoldipine	—	297
37	Nocodazole Nocodazole is	—	215
38	Masoprocol	—	300
39	Norepinephrine Precursor of epinephrine that is secreted by	—	298
40	o-Phthalaldehyde	—	300
41	Oxyphenbutazone	—	300
42	pivampicillin	—	275
43	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
44	Salmeterol Xinafoate	—	227
45	Tilorone	—	300
46	Urea	—	297
47	Kaempferols	—	300
48	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
49	pictilisib	—	25
50	Sorafenib	—	300

About the CREB phosphorylation Pathway

The CREB phosphorylation pathway is catalogued in Reactome (ID: R-HSA-199920) and involves 6 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, MAPKAPK2, RPS6KA1, RPS6KA2, RPS6KA3.