What genes are in the TCF dependent signaling in response to WNT pathway?

The TCF dependent signaling in response to WNT pathway involves 59 genes. Key genes include: ADRM1, ASH2L, CREBBP, CSNK1A1, CSNK1E, CSNK1G2, CSNK2A1, CSNK2A2, CSNK2B, CTBP1.

TCF dependent signaling in response to WNT

Q: What compounds affect the TCF dependent signaling in response to WNT pathway?

70 compounds in the BiohacksAI corpus have documented interactions with genes in the TCF dependent signaling in response to WNT pathway (Reactome ID: R-HSA-201681). These compounds target 59 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-20168159 genes70 compounds

The TCF dependent signaling in response to WNT pathway (Reactome ID: R-HSA-201681) involves 59 genes and is affected by 70 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ASH2L CREBBP CSNK1A1 CSNK1E CSNK1G2 CSNK2A1 CSNK2A2 CSNK2B CTBP1 DPY30 EP300 FZD1 GSK3B HDAC1 MEN1 MYC PPP2CA PPP2R5A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4+29 more

Compounds Affecting TCF dependent signaling in response to WNT

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	chrysin	—	300
7	egcg	—	300
8	sp600125	—	117
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	Kaempferols	—	300
11	fisetin	—	78
12	ly294002	—	11
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	s adenosylhomocysteine	—	300
15	alsterpaullone	—	12
16	Vanillic Acid	—	300
17	pictilisib	—	25
18	kenpaullone	—	8
19	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
20	Sorafenib	—	300
21	Ursolic Acid	—	300
22	celastrol	—	300
23	plumbagin [Supplementary Concept]	—	300
24	Okadaic Acid	—	300
25	indirubin	—	300
26	Lithium Chloride	—	300
27	Rutin	—	300
28	Oleanolic Acid	—	300
29	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
30	Dichlororibofuranosylbenzimidazole	—	26
31	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
32	Axitinib	—	298
33	Disulfiram	—	297
34	4-Hydroxybenzoate-3-Monooxygenase	—	300
35	Genistein	—	300
36	Vorinostat	—	299
37	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
38	scriptaid	—	53
39	Valproic Acid	—	296
40	Butyric Acid	—	300
41	Celecoxib	—	295
42	Daunorubicin	—	298
43	Camptothecin	—	300
44	Afatinib	—	297
45	Dasatinib	—	299
46	Adapalene	—	296
47	alpha-Linolenic Acid	—	300
48	prunetin	—	35
49	NAD	—	300
50	NAD	—	300

About the TCF dependent signaling in response to WNT Pathway

The TCF dependent signaling in response to WNT pathway is catalogued in Reactome (ID: R-HSA-201681) and involves 59 genes. In the BiohacksAI corpus, 70 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ASH2L, CREBBP, CSNK1A1, CSNK1E.