Metabolism of nitric oxide: NOS3 activation and regulation

Q: What compounds affect the Metabolism of nitric oxide: NOS3 activation and regulation pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of nitric oxide: NOS3 activation and regulation pathway (Reactome ID: R-HSA-202131). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-2021313 genes37 compounds

The Metabolism of nitric oxide: NOS3 activation and regulation pathway (Reactome ID: R-HSA-202131) involves 3 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HSP90AA1 LYPLA1 NOS3

Compounds Affecting Metabolism of nitric oxide: NOS3 activation and regulation

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	triolimus [Supplementary Concept]	—	33
3	monorden	—	8
4	gedunin	—	54
5	celastrol	—	300
6	Novobiocin	—	300
7	caffeic acid	—	300
8	Masoprocol	—	300
9	Tetracycline	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Quercetin	—	300
13	2-Chloroadenosine 2-Chloroadenosine.	—	300
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	ag490	—	14
16	Calcimycin	—	216
17	Calcitriol	—	300
18	Ciclopirox	—	88
19	Clotrimazole	—	296
20	cycloheximide	—	300
21	deguelin [Supplementary Concept]	—	151
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	NG-Nitroarginine Methyl Ester	—	238
32	Nitroarginine	—	300
33	Catechin	—	300
34	Arginine	—	300
35	Arginine	—	300
36	sesamol	—	293
37	palmostatin b	—	2

About the Metabolism of nitric oxide: NOS3 activation and regulation Pathway

The Metabolism of nitric oxide: NOS3 activation and regulation pathway is catalogued in Reactome (ID: R-HSA-202131) and involves 3 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HSP90AA1, LYPLA1, NOS3.