What genes are in the Downregulation of TGF-beta receptor signaling pathway?

The Downregulation of TGF-beta receptor signaling pathway involves 8 genes. Key genes include: PPP1CA, PPP1CC, SMAD2, SMAD3, TGFBR1, TGFBR2, UCHL5, XPO1.

Downregulation of TGF-beta receptor signaling

Q: What compounds affect the Downregulation of TGF-beta receptor signaling pathway?

80 compounds in the BiohacksAI corpus have documented interactions with genes in the Downregulation of TGF-beta receptor signaling pathway (Reactome ID: R-HSA-2173788). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21737888 genes80 compounds

The Downregulation of TGF-beta receptor signaling pathway (Reactome ID: R-HSA-2173788) involves 8 genes and is affected by 80 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PPP1CA PPP1CC SMAD2 SMAD3 TGFBR1 TGFBR2 UCHL5 XPO1

Compounds Affecting Downregulation of TGF-beta receptor signaling

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
3	Calcimycin	—	216
4	cycloheximide	—	300
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Disulfiram	—	297
8	Nisoldipine	—	297
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Kaempferols	—	300
11	Quercetin	—	300
12	Colchicine	—	300
13	Dactinomycin	—	297
14	Danazol	—	298
15	Dinitrochlorobenzene	—	300
16	Ethidium	—	300
17	Flutamide	—	298
18	Loratadine	—	296
19	Oxyphenbutazone	—	300
20	Podophyllotoxin	—	14
21	vinblastine sulfate	—	81
22	Vincristine	—	299
23	chrysin	—	300
24	egcg	—	300
25	Fluoxetine	—	1,000
26	Astemizole Antihistamine drug now withdrawn from	—	280
27	Bortezomib	—	300
28	Celecoxib	—	295
29	Ciclopirox	—	88
30	Cladribine	—	297
31	Daunorubicin	—	298
32	Domperidone	—	299
33	Emetine	—	298
34	Equilin	—	216
35	Ethinyl Estradiol	—	300
36	Ezetimibe	—	296
37	Fluspirilene	—	74
38	Hexachlorophene	—	300
39	Idazoxan	—	300
40	Lynestrenol	—	299
41	Nocodazole Nocodazole is	—	215
42	Masoprocol	—	300
43	o-Phthalaldehyde	—	300
44	Perphenazine	—	297
45	pivampicillin	—	275
46	Promethazine	—	121
47	Rotenone	—	300
48	Salmeterol Xinafoate	—	227
49	streptonigrin	—	299
50	Sulbactam	—	299

About the Downregulation of TGF-beta receptor signaling Pathway

The Downregulation of TGF-beta receptor signaling pathway is catalogued in Reactome (ID: R-HSA-2173788) and involves 8 genes. In the BiohacksAI corpus, 80 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PPP1CA, PPP1CC, SMAD2, SMAD3, TGFBR1.