What compounds affect the Mitotic Metaphase and Anaphase pathway?

74 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitotic Metaphase and Anaphase pathway (Reactome ID: R-HSA-2555396). These compounds target 66 genes within this pathway.

What genes are in the Mitotic Metaphase and Anaphase pathway?

The Mitotic Metaphase and Anaphase pathway involves 66 genes. Key genes include: ADRM1, AURKB, BIRC5, CCNB1, CCNB2, CDK1, HDAC8, KPNB1, LMNA, PLK1.

Mitotic Metaphase and Anaphase

REACTOME PATHWAY

Reactome: R-HSA-255539666 genes74 compounds

The Mitotic Metaphase and Anaphase pathway (Reactome ID: R-HSA-2555396) involves 66 genes and is affected by 74 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AURKB BIRC5 CCNB1 CCNB2 CDK1 HDAC8 KPNB1 LMNA PLK1 PPP1CC PPP2CA PPP2R5A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3+36 more

Compounds Affecting Mitotic Metaphase and Anaphase

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Reserpine	—	297
4	Nocodazole Nocodazole is	—	215
5	Vorinostat	—	299
6	Vincristine	—	299
7	Noscapine	—	300
8	Podophyllotoxin	—	14
9	Demecolcine	—	246
10	Maytansine	—	300
11	vinblastine sulfate	—	81
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	fisetin	—	78
15	Quercetin	—	300
16	kenpaullone	—	8
17	chrysin	—	300
18	Sorafenib	—	300
19	sp600125	—	117
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
21	alsterpaullone	—	12
22	indirubin	—	300
23	Okadaic Acid	—	300
24	Crizotinib	—	298
25	Dasatinib	—	299
26	Disulfiram	—	297
27	Hexachlorophene	—	300
28	Oxytetracycline	—	300
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
31	Axitinib	—	298
32	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
33	Kaempferols	—	300
34	hydroxyfasudil [Supplementary Concept]	—	11
35	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
36	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
37	scutellarein	—	113
38	tamarixetin	—	26
39	Clofibrate	—	299
40	Fenofibrate	—	297
41	Sertraline	—	1,000
42	Cinnarizine	—	299
43	Clotrimazole	—	296
44	Rotenone	—	300
45	ly294002	—	11
46	Wortmannin	—	300
47	Oleic Acid	—	112
48	Simvastatin	—	1,000
49	cefaclor	—	299
50	Lithocholic Acid	—	300

About the Mitotic Metaphase and Anaphase Pathway

The Mitotic Metaphase and Anaphase pathway is catalogued in Reactome (ID: R-HSA-2555396) and involves 66 genes. In the BiohacksAI corpus, 74 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AURKB, BIRC5, CCNB1, CCNB2.