What compounds affect the FCERI mediated NF-kB activation pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the FCERI mediated NF-kB activation pathway (Reactome ID: R-HSA-2871837). These compounds target 42 genes within this pathway.

What genes are in the FCERI mediated NF-kB activation pathway?

The FCERI mediated NF-kB activation pathway involves 42 genes. Key genes include: ADRM1, CHUK, CUL1, IKBKB, LYN, MAP3K7, NFKB1, NFKBIA, PDPK1, PSMA1.

FCERI mediated NF-kB activation

REACTOME PATHWAY

Reactome: R-HSA-287183742 genes68 compounds

The FCERI mediated NF-kB activation pathway (Reactome ID: R-HSA-2871837) involves 42 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CUL1 IKBKB LYN MAP3K7 NFKB1 NFKBIA PDPK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1+12 more

Compounds Affecting FCERI mediated NF-kB activation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	chicoric acid	—	117
4	Quercetin	—	300
5	Resveratrol	—	298
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	alsterpaullone	—	12
9	Crizotinib	—	298
10	sp600125	—	117
11	Podophyllotoxin	—	14
12	egcg	—	300
13	Kaempferols	—	300
14	Rutin	—	300
15	Withania	—	500
16	Disulfiram	—	297
17	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
18	tamarixetin	—	26
19	Trifluridine	—	295
20	tyrphostin ag 1478	—	4
21	withaferin	—	300
22	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
23	Sorafenib	—	300
24	kenpaullone	—	8
25	Hydrocortisone	—	299
26	Cerulenin	—	300
27	Chlorpropamide	—	300
28	daph	—	2
29	Hexachlorophene	—	300
30	Hydrocortisone	—	298
31	Lovastatin	—	300
32	ly294002	—	11
33	Promethazine	—	121
34	protriptyline	—	296
35	streptonigrin	—	299
36	Sulfaphenazole	—	300
37	Triamcinolone	—	300
38	tyrphostin 1	—	1
39	Voriconazole	—	299
40	Cathelicidins Antimicrobial cationic peptides with	—	300
41	plumbagin [Supplementary Concept]	—	300
42	Ursolic Acid	—	300
43	Oleanolic Acid	—	300
44	pyrrolidine dithiocarbamate	—	275
45	vinblastine sulfate	—	81
46	4-Hydroxybenzoate-3-Monooxygenase	—	300
47	chrysin	—	300
48	Genistein	—	300
49	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
50	naringin	—	300

About the FCERI mediated NF-kB activation Pathway

The FCERI mediated NF-kB activation pathway is catalogued in Reactome (ID: R-HSA-2871837) and involves 42 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CUL1, IKBKB, LYN.