What compounds affect the Nuclear Envelope Breakdown pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear Envelope Breakdown pathway (Reactome ID: R-HSA-2980766). These compounds target 8 genes within this pathway.

What genes are in the Nuclear Envelope Breakdown pathway?

The Nuclear Envelope Breakdown pathway involves 8 genes. Key genes include: CCNB1, CCNB2, CDK1, LMNA, NEK6, NEK7, NEK9, PLK1.

Nuclear Envelope Breakdown

REACTOME PATHWAY

Reactome: R-HSA-29807668 genes30 compounds

The Nuclear Envelope Breakdown pathway (Reactome ID: R-HSA-2980766) involves 8 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNB1 CCNB2 CDK1 LMNA NEK6 NEK7 NEK9 PLK1

Compounds Affecting Nuclear Envelope Breakdown

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	indirubin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	chrysin	—	300
6	fisetin	—	78
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Quercetin	—	300
9	Crizotinib	—	298
10	Clofibrate	—	299
11	Fenofibrate	—	297
12	Sertraline	—	1,000
13	Cinnarizine	—	299
14	Clotrimazole	—	296
15	Rotenone	—	300
16	Sorafenib	—	300
17	sp600125	—	117
18	ly294002	—	11
19	Wortmannin	—	300
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
21	Oleic Acid	—	112
22	Simvastatin	—	1,000
23	cefaclor	—	299
24	Disulfiram	—	297
25	Hexachlorophene	—	300
26	Lithocholic Acid	—	300
27	Nisoldipine	—	297
28	Oxyphenbutazone	—	300
29	Oxytetracycline	—	300
30	Histamine	—	300

About the Nuclear Envelope Breakdown Pathway

The Nuclear Envelope Breakdown pathway is catalogued in Reactome (ID: R-HSA-2980766) and involves 8 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CCNB2, CDK1, LMNA, NEK6.