What compounds affect the RMTs methylate histone arginines pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the RMTs methylate histone arginines pathway (Reactome ID: R-HSA-3214858). These compounds target 12 genes within this pathway.

What genes are in the RMTs methylate histone arginines pathway?

The RMTs methylate histone arginines pathway involves 12 genes. Key genes include: CARM1, CDK4, JAK2, PBRM1, PRMT1, PRMT3, PRMT5, PRMT6, PRMT7, SMARCA2.

RMTs methylate histone arginines

REACTOME PATHWAY

Reactome: R-HSA-321485812 genes42 compounds

The RMTs methylate histone arginines pathway (Reactome ID: R-HSA-3214858) involves 12 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CDK4 JAK2 PBRM1 PRMT1 PRMT3 PRMT5 PRMT6 PRMT7 SMARCA2 WDR5 WDR77

Compounds Affecting RMTs methylate histone arginines

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Disulfiram	—	297
3	same	—	299
4	s adenosylmethionine	—	300
5	pentamidine	—	299
6	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
7	Sulfinpyrazone	—	300
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	Calcimycin	—	216
10	cefaclor	—	299
11	Cefixime	—	300
12	Cefotetan	—	299
13	Demeclocycline	—	5
14	Ethidium	—	300
15	hydroxyindoleacetic acid	—	300
16	Metergoline	—	144
17	Nisoldipine	—	297
18	Nitrofurantoin	—	297
19	Suramin	—	300
20	Azauridine	—	300
21	Cladribine	—	297
22	Dasatinib	—	299
23	Methylene Blue	—	200
24	2-Methoxyestradiol	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Azathioprine	—	300
27	Calcitriol	—	300
28	Camptothecin	—	300
29	Cytarabine	—	297
30	dihydrorotenone	—	13
31	Podophyllotoxin	—	14
32	streptonigrin	—	299
33	Trifluridine	—	295
34	Tripterygium	—	300
35	Genistein	—	300
36	alsterpaullone	—	12
37	calycosin	—	300
38	kenpaullone	—	8
39	chrysin	—	300
40	Lovastatin	—	300
41	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
42	indirubin	—	300

About the RMTs methylate histone arginines Pathway

The RMTs methylate histone arginines pathway is catalogued in Reactome (ID: R-HSA-3214858) and involves 12 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CDK4, JAK2, PBRM1, PRMT1.