What compounds affect the Loss of Function of SMAD2/3 in Cancer pathway?

67 compounds in the BiohacksAI corpus have documented interactions with genes in the Loss of Function of SMAD2/3 in Cancer pathway (Reactome ID: R-HSA-3304349). These compounds target 4 genes within this pathway.

What genes are in the Loss of Function of SMAD2/3 in Cancer pathway?

The Loss of Function of SMAD2/3 in Cancer pathway involves 4 genes. Key genes include: SMAD2, SMAD3, TGFBR1, TGFBR2.

Loss of Function of SMAD2/3 in Cancer

REACTOME PATHWAY

Reactome: R-HSA-33043494 genes67 compounds

The Loss of Function of SMAD2/3 in Cancer pathway (Reactome ID: R-HSA-3304349) involves 4 genes and is affected by 67 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SMAD2 SMAD3 TGFBR1 TGFBR2

Compounds Affecting Loss of Function of SMAD2/3 in Cancer

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	cycloheximide	—	300
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Disulfiram	—	297
6	Nisoldipine	—	297
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Kaempferols	—	300
9	Quercetin	—	300
10	Colchicine	—	300
11	Dactinomycin	—	297
12	Danazol	—	298
13	Dinitrochlorobenzene	—	300
14	Ethidium	—	300
15	Flutamide	—	298
16	Loratadine	—	296
17	Oxyphenbutazone	—	300
18	Podophyllotoxin	—	14
19	vinblastine sulfate	—	81
20	Vincristine	—	299
21	chrysin	—	300
22	egcg	—	300
23	Fluoxetine	—	1,000
24	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Bortezomib	—	300
27	Celecoxib	—	295
28	Ciclopirox	—	88
29	Cladribine	—	297
30	Daunorubicin	—	298
31	Domperidone	—	299
32	Emetine	—	298
33	Equilin	—	216
34	Ethinyl Estradiol	—	300
35	Ezetimibe	—	296
36	Idazoxan	—	300
37	Lynestrenol	—	299
38	Nocodazole Nocodazole is	—	215
39	Masoprocol	—	300
40	o-Phthalaldehyde	—	300
41	Perphenazine	—	297
42	pivampicillin	—	275
43	Promethazine	—	121
44	Rotenone	—	300
45	Salmeterol Xinafoate	—	227
46	Sulbactam	—	299
47	trequinsin hydrochloride	—	1
48	triflupromazine hydrochloride	—	12
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Calcimycin	—	216

About the Loss of Function of SMAD2/3 in Cancer Pathway

The Loss of Function of SMAD2/3 in Cancer pathway is catalogued in Reactome (ID: R-HSA-3304349) and involves 4 genes. In the BiohacksAI corpus, 67 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SMAD2, SMAD3, TGFBR1, TGFBR2.