What compounds affect the SMAD4 MH2 Domain Mutants in Cancer pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the SMAD4 MH2 Domain Mutants in Cancer pathway (Reactome ID: R-HSA-3311021). These compounds target 2 genes within this pathway.

What genes are in the SMAD4 MH2 Domain Mutants in Cancer pathway?

The SMAD4 MH2 Domain Mutants in Cancer pathway involves 2 genes. Key genes include: SMAD2, SMAD3.

SMAD4 MH2 Domain Mutants in Cancer

REACTOME PATHWAY

Reactome: R-HSA-33110212 genes63 compounds

The SMAD4 MH2 Domain Mutants in Cancer pathway (Reactome ID: R-HSA-3311021) involves 2 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SMAD2 SMAD3

Compounds Affecting SMAD4 MH2 Domain Mutants in Cancer

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	Disulfiram	—	297
5	Nisoldipine	—	297
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Quercetin	—	300
9	Colchicine	—	300
10	Dactinomycin	—	297
11	Danazol	—	298
12	Dasatinib	—	299
13	Dinitrochlorobenzene	—	300
14	Ethidium	—	300
15	Flutamide	—	298
16	Loratadine	—	296
17	Oxyphenbutazone	—	300
18	Podophyllotoxin	—	14
19	vinblastine sulfate	—	81
20	Vincristine	—	299
21	chrysin	—	300
22	egcg	—	300
23	Fluoxetine	—	1,000
24	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	Bortezomib	—	300
27	Celecoxib	—	295
28	Ciclopirox	—	88
29	Cladribine	—	297
30	Daunorubicin	—	298
31	Domperidone	—	299
32	Emetine	—	298
33	Equilin	—	216
34	Ethinyl Estradiol	—	300
35	Ezetimibe	—	296
36	Idazoxan	—	300
37	Lynestrenol	—	299
38	Nocodazole Nocodazole is	—	215
39	Masoprocol	—	300
40	o-Phthalaldehyde	—	300
41	Perphenazine	—	297
42	pivampicillin	—	275
43	Promethazine	—	121
44	Rotenone	—	300
45	Salmeterol Xinafoate	—	227
46	Sulbactam	—	299
47	trequinsin hydrochloride	—	1
48	triflupromazine hydrochloride	—	12
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Calcimycin	—	216

About the SMAD4 MH2 Domain Mutants in Cancer Pathway

The SMAD4 MH2 Domain Mutants in Cancer pathway is catalogued in Reactome (ID: R-HSA-3311021) and involves 2 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SMAD2, SMAD3.