What compounds affect the HSF1 activation pathway?

64 compounds in the BiohacksAI corpus have documented interactions with genes in the HSF1 activation pathway (Reactome ID: R-HSA-3371511). These compounds target 5 genes within this pathway.

What genes are in the HSF1 activation pathway?

The HSF1 activation pathway involves 5 genes. Key genes include: HDAC6, HSP90AA1, HSP90AB1, PTGES3, VCP.

HSF1 activation

REACTOME PATHWAY

Reactome: R-HSA-33715115 genes64 compounds

The HSF1 activation pathway (Reactome ID: R-HSA-3371511) involves 5 genes and is affected by 64 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HDAC6 HSP90AA1 HSP90AB1 PTGES3 VCP

Compounds Affecting HSF1 activation

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Quercetin	—	300
3	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
4	piceatannol	—	300
5	gedunin	—	54
6	triolimus [Supplementary Concept]	—	33
7	monorden	—	8
8	celastrol	—	300
9	Novobiocin	—	300
10	caffeic acid	—	300
11	Masoprocol	—	300
12	Tetracycline	—	300
13	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
14	ag490	—	14
15	Clotrimazole	—	296
16	Hexachlorophene	—	300
17	Idarubicin	—	299
18	Nitroprusside	—	299
19	Vorinostat	—	299
20	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
21	scriptaid	—	53
22	pictilisib	—	25
23	Valproic Acid	—	296
24	Daunorubicin	—	298
25	Ursolic Acid	—	300
26	Butyric Acid	—	300
27	Celecoxib	—	295
28	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
29	chrysin	—	300
30	Pueraria	—	300
31	fisetin	—	78
32	Genistein	—	300
33	Kaempferols	—	300
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
35	pterostilbene	—	299
36	Axitinib	—	298
37	Bufexamac	—	137
38	butein	—	158
39	Camptothecin	—	300
40	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
41	Febuxostat	—	297
42	Hesperidin	—	300
43	pd98059	—	7
44	sp600125	—	117
45	stx64	—	2
46	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
47	triflupromazine hydrochloride	—	12
48	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester [Supplementary Concept]	—	100
49	2-Chloroadenosine 2-Chloroadenosine.	—	300
50	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300

About the HSF1 activation Pathway

The HSF1 activation pathway is catalogued in Reactome (ID: R-HSA-3371511) and involves 5 genes. In the BiohacksAI corpus, 64 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HDAC6, HSP90AA1, HSP90AB1, PTGES3, VCP.