What compounds affect the Unfolded Protein Response (UPR) pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the Unfolded Protein Response (UPR) pathway (Reactome ID: R-HSA-381119). These compounds target 10 genes within this pathway.

What genes are in the Unfolded Protein Response (UPR) pathway?

The Unfolded Protein Response (UPR) pathway involves 10 genes. Key genes include: ATF6, CCL2, CXCL8, EIF2AK3, ERN1, GSK3A, HSP90B1, HSPA5, LMNA, XBP1.

Unfolded Protein Response (UPR)

REACTOME PATHWAY

Reactome: R-HSA-38111910 genes41 compounds

The Unfolded Protein Response (UPR) pathway (Reactome ID: R-HSA-381119) involves 10 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATF6 CCL2 CXCL8 EIF2AK3 ERN1 GSK3A HSP90B1 HSPA5 LMNA XBP1

Compounds Affecting Unfolded Protein Response (UPR)

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	2-Chloroadenosine 2-Chloroadenosine.	—	300
3	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
4	alsterpaullone	—	12
5	indirubin	—	300
6	kenpaullone	—	8
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	fisetin	—	78
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Quercetin	—	300
14	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
15	Chlorhexidine	—	299
16	piceatannol	—	300
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Colchicine	—	300
19	Vitamin	—	295
20	Bromodeoxyuridine	—	300
21	Dacarbazine	—	299
22	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
23	Ethinyl Estradiol	—	300
24	Indomethacin	—	297
25	Retinaldehyde	—	300
26	Tolmetin	—	298
27	Toxaphene	—	299
28	fluoranthene	—	300
29	Ethoxyquin Antioxidant; also	—	180
30	Methylcholanthrene	—	300
31	Mometasone Furoate	—	292
32	Masoprocol	—	300
33	aniracetam	—	110
34	Camptothecin	—	300
35	Adenosine Triphosphate	—	300
36	Hexachlorophene	—	300
37	Ergosterol	—	300
38	Calcimycin	—	216
39	Fluspirilene	—	74
40	hydroxyfasudil [Supplementary Concept]	—	11
41	Histamine	—	300

About the Unfolded Protein Response (UPR) Pathway

The Unfolded Protein Response (UPR) pathway is catalogued in Reactome (ID: R-HSA-381119) and involves 10 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATF6, CCL2, CXCL8, EIF2AK3, ERN1.