Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Q: What compounds affect the Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway (Reactome ID: R-HSA-381426). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3814269 genes49 compounds

The Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway (Reactome ID: R-HSA-381426) involves 9 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ALB APP CTSG F5 HSP90B1 IL6 MEN1 P4HB

Compounds Affecting Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Kaempferols	—	300
3	Catechin	—	300
4	Resveratrol	—	298
5	Quercetin	—	300
6	Hesperidin	—	300
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Methylene Blue	—	200
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	caffeic acid	—	300
13	Vitamin	—	295
14	2-Methoxyestradiol	—	300
15	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
16	Cladribine	—	297
17	Digitoxin	—	300
18	Digoxin	—	299
19	Disulfiram	—	297
20	Edetic Acid	—	24
21	Vanillic Acid	—	300
22	Ouabain	—	300
23	Podophyllotoxin	—	14
24	Quinic Acid	—	218
25	Retinaldehyde	—	300
26	streptonigrin	—	299
27	Trifluridine	—	295
28	Warfarin	—	1,000
29	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
30	Tolbutamide	—	300
31	cbd	—	298
32	cannabidiol	—	296
33	Evans Blue	—	300
34	Olmesartan Medoxomil	—	300
35	Phenylbutazone	—	300
36	Trazodone	—	297
37	Bisphenol A-Glycidyl Methacrylate	—	197
38	Progesterone	—	299
39	Hexachlorophene	—	300
40	2-Chloroadenosine 2-Chloroadenosine.	—	300
41	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
42	Adenosine Triphosphate	—	300
43	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
44	Nitroblue Tetrazolium Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases,	—	300
45	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
46	Equilin	—	216
47	apixaban [Supplementary Concept]	—	997
48	Prednisolone	—	1,000
49	Bortezomib	—	300

About the Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway

The Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway is catalogued in Reactome (ID: R-HSA-381426) and involves 9 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ALB, APP, CTSG, F5.