What genes are in the Glyoxylate metabolism and glycine degradation pathway?

The Glyoxylate metabolism and glycine degradation pathway involves 2 genes. Key genes include: DLD, GNMT.

Glyoxylate metabolism and glycine degradation

Q: What compounds affect the Glyoxylate metabolism and glycine degradation pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the Glyoxylate metabolism and glycine degradation pathway (Reactome ID: R-HSA-389661). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3896612 genes42 compounds

The Glyoxylate metabolism and glycine degradation pathway (Reactome ID: R-HSA-389661) involves 2 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DLD GNMT

Compounds Affecting Glyoxylate metabolism and glycine degradation

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Calcimycin	—	216
3	Dequalinium	—	136
4	Ticagrelor	—	299
5	tyrphostin ag 1478	—	4
6	Aurintricarboxylic Acid	—	184
7	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
8	Chlorhexidine	—	299
9	Cisplatin	—	300
10	darapladib [Supplementary Concept]	—	44
11	Dasatinib	—	299
12	Demeclocycline	—	297
13	Iodoacetamide	—	300
14	pictilisib	—	25
15	Vemurafenib	—	298
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	Thyroxine	—	994
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Quercetin	—	300
20	2-Methoxyestradiol	—	300
21	Afatinib	—	297
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
23	Disulfiram	—	297
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Estrone	—	300
26	Guanabenz	—	298
27	Methyldopa	—	297
28	Methylergonovine	—	193
29	Methysergide	—	300
30	piceatannol	—	300
31	propionylpromazine hydrochloride	—	2
32	scriptaid	—	53
33	Suramin	—	300
34	Thiorphan	—	300
35	Thyroxine	—	300
36	Triiodothyronine	—	300
37	tyrphostin 9	—	2
38	egcg	—	300
39	Rutin	—	300
40	Oxaprozin	—	181
41	Pioglitazone	—	297
42	streptonigrin	—	299

About the Glyoxylate metabolism and glycine degradation Pathway

The Glyoxylate metabolism and glycine degradation pathway is catalogued in Reactome (ID: R-HSA-389661) and involves 2 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DLD, GNMT.