Question 1

What compounds affect the EPHA-mediated growth cone collapse pathway?

Accepted Answer

27 compounds in the BiohacksAI corpus have documented interactions with genes in the EPHA-mediated growth cone collapse pathway (Reactome ID: R-HSA-3928663). These compounds target 13 genes within this pathway.

Question 2

What genes are in the EPHA-mediated growth cone collapse pathway?

Accepted Answer

The EPHA-mediated growth cone collapse pathway involves 13 genes. Key genes include: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, FYN, LYN.

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	Dasatinib	—	299
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	alsterpaullone	—	12
7	sp600125	—	117
8	Quercetin	—	300
9	Afatinib	—	297
10	Axitinib	—	298
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Cladribine	—	297
14	pictilisib	—	25
15	Pioglitazone	—	297
16	Vemurafenib	—	298
17	Resveratrol	—	298
18	Adenosine Monophosphate Adenine nucleotide containing	—	300
19	monorden	—	8
20	Niclosamide	—	299
21	Rosmarinic Acid	—	300
22	Genistein	—	300
23	egcg	—	300
24	Acetic Acid Product of	—	300
25	hydroxyfasudil [Supplementary Concept]	—	11
26	Kinetin	—	300
27	Edaravone	—	298

BiohacksAI

EPHA-mediated growth cone collapse

Genes in this Pathway

Compounds Affecting EPHA-mediated growth cone collapse

About the EPHA-mediated growth cone collapse Pathway