What compounds affect the Trafficking of AMPA receptors pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the Trafficking of AMPA receptors pathway (Reactome ID: R-HSA-399719). These compounds target 7 genes within this pathway.

What genes are in the Trafficking of AMPA receptors pathway?

The Trafficking of AMPA receptors pathway involves 7 genes. Key genes include: CAMK2B, CAMK2D, GRIA1, GRIA2, GRIA3, GRIA4, MDM2.

Trafficking of AMPA receptors

REACTOME PATHWAY

Reactome: R-HSA-3997197 genes62 compounds

The Trafficking of AMPA receptors pathway (Reactome ID: R-HSA-399719) involves 7 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D GRIA1 GRIA2 GRIA3 GRIA4 MDM2

Compounds Affecting Trafficking of AMPA receptors

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
4	aniracetam	—	110
5	Piracetam	—	300
6	sp600125	—	117
7	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
8	Digoxin	—	299
9	Calcimycin	—	216
10	cycloheximide	—	300
11	Cytarabine	—	297
12	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
13	Niclosamide	—	299
14	Tubercidin	—	300
15	Anisomycin	—	247
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Azacitidine	—	298
18	Azacitidine	—	300
19	Chlorhexidine	—	299
20	Ciclopirox	—	88
21	Cladribine	—	297
22	Colchicine	—	300
23	colchine	—	2
24	Demecolcine	—	246
25	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
26	Fluspirilene	—	74
27	gedunin	—	54
28	Hexachlorophene	—	300
29	lidoflazine	—	278
30	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
31	Nisoldipine	—	297
32	Nocodazole Nocodazole is	—	215
33	Ouabain	—	300
34	paxilline	—	42
35	Podophyllotoxin	—	14
36	rafoxanide	—	172
37	streptonigrin	—	299
38	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
39	Trifluridine	—	295
40	tyrphostin 9	—	2
41	vinblastine sulfate	—	81
42	Methylene Blue	—	200
43	Sertraline	—	1,000
44	Simvastatin	—	1,000
45	Ursolic Acid	—	300
46	Methotrexate	—	289
47	Aripiprazole	—	298
48	cardamonin	—	180
49	dihydrorotenone	—	13
50	Dinitrochlorobenzene	—	300

About the Trafficking of AMPA receptors Pathway

The Trafficking of AMPA receptors pathway is catalogued in Reactome (ID: R-HSA-399719) and involves 7 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, GRIA1, GRIA2, GRIA3.