Glutamate binding, activation of AMPA receptors and synaptic plasticity

Q: What compounds affect the Glutamate binding, activation of AMPA receptors and synaptic plasticity pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the Glutamate binding, activation of AMPA receptors and synaptic plasticity pathway (Reactome ID: R-HSA-399721). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3997217 genes62 compounds

The Glutamate binding, activation of AMPA receptors and synaptic plasticity pathway (Reactome ID: R-HSA-399721) involves 7 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D GRIA1 GRIA2 GRIA3 GRIA4 MDM2

Compounds Affecting Glutamate binding, activation of AMPA receptors and synaptic plasticity

#	Compound	Targets Hit	Studies
1	Glutamic Acid	—	297
2	Glutamic Acid	—	300
3	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
4	aniracetam	—	110
5	Piracetam	—	300
6	sp600125	—	117
7	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
8	Digoxin	—	299
9	Calcimycin	—	216
10	cycloheximide	—	300
11	Cytarabine	—	297
12	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
13	Niclosamide	—	299
14	Tubercidin	—	300
15	Anisomycin	—	247
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Azacitidine	—	298
18	Azacitidine	—	300
19	Chlorhexidine	—	299
20	Ciclopirox	—	88
21	Cladribine	—	297
22	Colchicine	—	300
23	colchine	—	2
24	Demecolcine	—	246
25	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
26	Fluspirilene	—	74
27	gedunin	—	54
28	Hexachlorophene	—	300
29	lidoflazine	—	278
30	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
31	Nisoldipine	—	297
32	Nocodazole Nocodazole is	—	215
33	Ouabain	—	300
34	paxilline	—	42
35	Podophyllotoxin	—	14
36	rafoxanide	—	172
37	streptonigrin	—	299
38	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
39	Trifluridine	—	295
40	tyrphostin 9	—	2
41	vinblastine sulfate	—	81
42	Methylene Blue	—	200
43	Sertraline	—	1,000
44	Simvastatin	—	1,000
45	Ursolic Acid	—	300
46	Methotrexate	—	289
47	Aripiprazole	—	298
48	cardamonin	—	180
49	dihydrorotenone	—	13
50	Dinitrochlorobenzene	—	300

About the Glutamate binding, activation of AMPA receptors and synaptic plasticity Pathway

The Glutamate binding, activation of AMPA receptors and synaptic plasticity pathway is catalogued in Reactome (ID: R-HSA-399721) and involves 7 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, GRIA1, GRIA2, GRIA3.