What compounds affect the cGMP effects pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the cGMP effects pathway (Reactome ID: R-HSA-418457). These compounds target 9 genes within this pathway.

What genes are in the cGMP effects pathway?

The cGMP effects pathway involves 9 genes. Key genes include: KCNMA1, KCNMB1, KCNMB2, KCNMB4, PDE10A, PDE1A, PDE1B, PDE2A, PDE5A.

cGMP effects

REACTOME PATHWAY

Reactome: R-HSA-4184579 genes54 compounds

The cGMP effects pathway (Reactome ID: R-HSA-418457) involves 9 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

KCNMA1 KCNMB1 KCNMB2 KCNMB4 PDE10A PDE1A PDE1B PDE2A PDE5A

Compounds Affecting cGMP effects

#	Compound	Targets Hit	Studies
1	Papaverine	—	299
2	pterostilbene	—	299
3	Carvedilol	—	296
4	Fluocinolone Acetonide	—	295
5	Latanoprost	—	299
6	Nisoldipine	—	297
7	Promethazine	—	121
8	Thioridazine	—	35
9	nafadotride	—	14
10	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
11	Nortriptyline	—	28
12	Perphenazine	—	297
13	Ritonavir	—	298
14	Budesonide	—	1,000
15	Resveratrol	—	298
16	Ethylestrenol	—	70
17	Ezetimibe	—	296
18	Thyroxine	—	994
19	Amoxapine	—	259
20	Thyroxine	—	300
21	Glyburide	—	298
22	Irbesartan	—	298
23	Simvastatin	—	1,000
24	Oxcarbazepine	—	296
25	Ursodeoxycholic Acid	—	298
26	Lovastatin	—	300
27	Nicardipine	—	94
28	vinpocetine	—	299
29	Oxaprozin	—	181
30	Calcitriol	—	300
31	Chlorpheniramine	—	157
32	Desoximetasone	—	86
33	Disulfiram	—	297
34	Etodolac	—	296
35	Levonorgestrel	—	292
36	Norgestrel	—	300
37	Amdinocillin	—	100
38	Aminolevulinic Acid	—	299
39	Artemether	—	299
40	Cetirizine	—	296
41	Ethinyl Estradiol	—	300
42	Pemoline	—	300
43	Tocainide	—	299
44	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
45	Methyltestosterone	—	300
46	Nateglinide	—	295
47	Flutamide	—	298
48	Imatinib Mesylate	—	300
49	L 741519 [Supplementary Concept]	—	25
50	Torsemide	—	245

About the cGMP effects Pathway

The cGMP effects pathway is catalogued in Reactome (ID: R-HSA-418457) and involves 9 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KCNMA1, KCNMB1, KCNMB2, KCNMB4, PDE10A.