What compounds affect the Sphingolipid metabolism pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the Sphingolipid metabolism pathway (Reactome ID: R-HSA-428157). These compounds target 19 genes within this pathway.

What genes are in the Sphingolipid metabolism pathway?

The Sphingolipid metabolism pathway involves 19 genes. Key genes include: ABCC1, ABCG2, ARSA, CSNK1G2, CTSA, GBA1, GLA, NEU2, NEU3, OSBP.

Sphingolipid metabolism

REACTOME PATHWAY

Reactome: R-HSA-42815719 genes53 compounds

The Sphingolipid metabolism pathway (Reactome ID: R-HSA-428157) involves 19 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCG2 ARSA CSNK1G2 CTSA GBA1 GLA NEU2 NEU3 OSBP PRKD1 PRKD2 PRKD3 SPHK1 SPHK2 SPTLC1 SPTLC2 SPTLC3 STS

Compounds Affecting Sphingolipid metabolism

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	hydroxyfasudil [Supplementary Concept]	—	11
3	Crizotinib	—	298
4	sp600125	—	117
5	myriocin	—	80
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Genistein	—	300
8	Kaempferols	—	300
9	Daunorubicin	—	298
10	Delavirdine	—	296
11	Dehydroepiandrosterone Sulfate	—	300
12	Sphingosine	—	300
13	Zanamivir	—	297
14	licochalcone	—	267
15	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
16	chrysin	—	300
17	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
18	Atorvastatin	—	1,000
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	Sirolimus	—	300
21	Avapritinib	—	246
22	candesartan cilexetil [Supplementary Concept]	—	300
23	Caspofungin	—	299
24	Estrone	—	300
25	Febuxostat	—	297
26	Fenofibrate	—	297
27	Furosemide	—	298
28	Sorafenib	—	300
29	Topotecan	—	300
30	Rimonabant	—	300
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
32	Kaempferols	—	300
33	Abacavir	—	295
34	Emtricitabine	—	292
35	Flurandrenolone	—	65
36	Indomethacin	—	297
37	Lamivudine	—	299
38	tiopronin	—	299
39	Triamcinolone	—	300
40	Triamcinolone Acetonide	—	300
41	Chlorhexidine	—	299
42	1-Deoxynojirimycin	—	299
43	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
44	Iodoacetamide	—	300
45	Pindolol	—	299
46	Pseudoephedrine	—	298
47	alsterpaullone	—	12
48	stx64	—	2
49	Oseltamivir	—	297
50	piceatannol	—	300

About the Sphingolipid metabolism Pathway

The Sphingolipid metabolism pathway is catalogued in Reactome (ID: R-HSA-428157) and involves 19 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCG2, ARSA, CSNK1G2, CTSA.