What compounds affect the RSK activation pathway?

27 compounds in the BiohacksAI corpus have documented interactions with genes in the RSK activation pathway (Reactome ID: R-HSA-444257). These compounds target 7 genes within this pathway.

What genes are in the RSK activation pathway?

The RSK activation pathway involves 7 genes. Key genes include: MAPK1, MAPK3, PDPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6.

RSK activation

REACTOME PATHWAY

Reactome: R-HSA-4442577 genes27 compounds

The RSK activation pathway (Reactome ID: R-HSA-444257) involves 7 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAPK1 MAPK3 PDPK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

Compounds Affecting RSK activation

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	fisetin	—	78
3	Sorafenib	—	300
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	plumbagin [Supplementary Concept]	—	300
7	pd98059	—	7
8	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
9	trametinib	—	296
10	withaferin	—	300
11	hydroxyfasudil [Supplementary Concept]	—	11
12	pictilisib	—	25
13	tyrphostin ag 1478	—	4
14	Clotrimazole	—	296
15	Progesterone	—	299
16	2-Chloroadenosine 2-Chloroadenosine.	—	300
17	Benzalkonium Compounds	—	299
18	Calcimycin	—	216
19	daph	—	2
20	Diphenhydramine	—	14
21	ha1004	—	4
22	Lithocholic Acid	—	300
23	Loratadine	—	296
24	trequinsin hydrochloride	—	1
25	Kaempferols	—	300
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	Afatinib	—	297

About the RSK activation Pathway

The RSK activation pathway is catalogued in Reactome (ID: R-HSA-444257) and involves 7 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAPK1, MAPK3, PDPK1, RPS6KA1, RPS6KA2.