Regulation of mRNA stability by proteins that bind AU-rich elements

Q: What compounds affect the Regulation of mRNA stability by proteins that bind AU-rich elements pathway?

75 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of mRNA stability by proteins that bind AU-rich elements pathway (Reactome ID: R-HSA-450531). These compounds target 44 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-45053144 genes75 compounds

The Regulation of mRNA stability by proteins that bind AU-rich elements pathway (Reactome ID: R-HSA-450531) involves 44 genes and is affected by 75 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 EIF4G1 ELAVL1 HSPA1A HSPA1B HSPA8 HSPB1 MAPK11 MAPK14 MAPKAPK2 PABPC1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5+14 more

Compounds Affecting Regulation of mRNA stability by proteins that bind AU-rich elements

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Hexachlorophene	—	300
5	egcg	—	300
6	Afatinib	—	297
7	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
8	Ergosterol	—	300
9	Adenosine Triphosphate	—	300
10	Disulfiram	—	297
11	Phenoxybenzamine	—	21
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
14	Sorafenib	—	300
15	Dasatinib	—	299
16	Anisomycin	—	247
17	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
18	withaferin	—	300
19	Oxytetracycline	—	300
20	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
21	Vitamin	—	295
22	Bufotenin	—	93
23	Clotrimazole	—	296
24	Feprazone	—	63
25	Nocodazole Nocodazole is	—	215
26	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
27	Adapalene	—	296
28	alpha-Linolenic Acid	—	300
29	Ciclopirox	—	88
30	Danazol	—	298
31	eliprodil	—	33
32	Ethinyl Estradiol	—	300
33	Ethoxyquin Antioxidant; also	—	180
34	Idazoxan	—	300
35	Leflunomide	—	297
36	Linoleic Acid	—	300
37	Lithocholic Acid	—	300
38	Methimazole	—	295
39	Methylcholanthrene	—	300
40	Methylnitrosourea	—	300
41	Mometasone Furoate	—	292
42	Nisoldipine	—	297
43	Masoprocol	—	300
44	Oxymetholone	—	298
45	rafoxanide	—	172
46	Sulfathiazole	—	300
47	Toxaphene	—	299
48	Triamcinolone Acetonide	—	300
49	Troglitazone	—	299
50	vinblastine sulfate	—	81

About the Regulation of mRNA stability by proteins that bind AU-rich elements Pathway

The Regulation of mRNA stability by proteins that bind AU-rich elements pathway is catalogued in Reactome (ID: R-HSA-450531) and involves 44 genes. In the BiohacksAI corpus, 75 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, EIF4G1, ELAVL1, HSPA1A, HSPA1B.