What genes are in the SUMOylation of DNA replication proteins pathway?

The SUMOylation of DNA replication proteins pathway involves 8 genes. Key genes include: AURKA, AURKB, BIRC5, PCNA, SUMO1, TOP1, TOP2A, TOP2B.

SUMOylation of DNA replication proteins

Q: What compounds affect the SUMOylation of DNA replication proteins pathway?

39 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of DNA replication proteins pathway (Reactome ID: R-HSA-4615885). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-46158858 genes39 compounds

The SUMOylation of DNA replication proteins pathway (Reactome ID: R-HSA-4615885) involves 8 genes and is affected by 39 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKA AURKB BIRC5 PCNA SUMO1 TOP1 TOP2A TOP2B

Compounds Affecting SUMOylation of DNA replication proteins

#	Compound	Targets Hit	Studies
1	fisetin	—	78
2	Quercetin	—	300
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
5	Ethidium	—	300
6	Topotecan	—	300
7	Sorafenib	—	300
8	sp600125	—	117
9	Axitinib	—	298
10	Crizotinib	—	298
11	kenpaullone	—	8
12	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Daunorubicin	—	298
15	Ciprofloxacin	—	1,000
16	Digitoxin	—	300
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	Kaempferols	—	300
19	Dasatinib	—	299
20	hydroxyfasudil [Supplementary Concept]	—	11
21	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
22	scutellarein	—	113
23	tamarixetin	—	26
24	Genistein	—	300
25	Teniposide	—	299
26	Aclarubicin	—	300
27	Dexrazoxane	—	298
28	Epirubicin	—	300
29	Idarubicin	—	299
30	Camptothecin	—	300
31	Irinotecan	—	298
32	Cefdinir	—	298
33	Cefixime	—	300
34	Hexachlorophene	—	300
35	Oxytetracycline	—	300
36	Buthionine Sulfoximine	—	300
37	Vitamin K 3	—	300
38	Oleanolic Acid	—	300
39	Triiodothyronine	—	300

About the SUMOylation of DNA replication proteins Pathway

The SUMOylation of DNA replication proteins pathway is catalogued in Reactome (ID: R-HSA-4615885) and involves 8 genes. In the BiohacksAI corpus, 39 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKA, AURKB, BIRC5, PCNA, SUMO1.