What compounds affect the RIPK1-mediated regulated necrosis pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the RIPK1-mediated regulated necrosis pathway (Reactome ID: R-HSA-5213460). These compounds target 4 genes within this pathway.

What genes are in the RIPK1-mediated regulated necrosis pathway?

The RIPK1-mediated regulated necrosis pathway involves 4 genes. Key genes include: CDC37, HSP90AA1, PRKN, RIPK3.

RIPK1-mediated regulated necrosis

REACTOME PATHWAY

Reactome: R-HSA-52134604 genes37 compounds

The RIPK1-mediated regulated necrosis pathway (Reactome ID: R-HSA-5213460) involves 4 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 HSP90AA1 PRKN RIPK3

Compounds Affecting RIPK1-mediated regulated necrosis

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	Hexachlorophene	—	300
4	triolimus [Supplementary Concept]	—	33
5	monorden	—	8
6	gedunin	—	54
7	Novobiocin	—	300
8	caffeic acid	—	300
9	Masoprocol	—	300
10	Tetracycline	—	300
11	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Quercetin	—	300
14	2-Chloroadenosine 2-Chloroadenosine.	—	300
15	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
16	ag490	—	14
17	Calcimycin	—	216
18	Calcitriol	—	300
19	Ciclopirox	—	88
20	Clotrimazole	—	296
21	cycloheximide	—	300
22	deguelin [Supplementary Concept]	—	151
23	Disulfiram	—	297
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
32	kenpaullone	—	8
33	Genistein	—	300
34	amn082	—	29
35	Medroxyprogesterone Acetate	—	299
36	Nitrendipine	—	299
37	Vemurafenib	—	298

About the RIPK1-mediated regulated necrosis Pathway

The RIPK1-mediated regulated necrosis pathway is catalogued in Reactome (ID: R-HSA-5213460) and involves 4 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, HSP90AA1, PRKN, RIPK3.