What compounds affect the IkBA variant leads to EDA-ID pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the IkBA variant leads to EDA-ID pathway (Reactome ID: R-HSA-5603029). These compounds target 6 genes within this pathway.

What genes are in the IkBA variant leads to EDA-ID pathway?

The IkBA variant leads to EDA-ID pathway involves 6 genes. Key genes include: CHUK, IKBKB, NFKB1, NFKB2, NFKBIA, RELA.

IkBA variant leads to EDA-ID

REACTOME PATHWAY

Reactome: R-HSA-56030296 genes43 compounds

The IkBA variant leads to EDA-ID pathway (Reactome ID: R-HSA-5603029) involves 6 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHUK IKBKB NFKB1 NFKB2 NFKBIA RELA

Compounds Affecting IkBA variant leads to EDA-ID

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Quercetin	—	300
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Rutin	—	300
9	Withania	—	500
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	tamarixetin	—	26
12	withaferin	—	300
13	Podophyllotoxin	—	14
14	Trifluridine	—	295
15	Hydrocortisone	—	299
16	egcg	—	300
17	Cerulenin	—	300
18	Chlorpropamide	—	300
19	daph	—	2
20	Disulfiram	—	297
21	Hexachlorophene	—	300
22	Hydrocortisone	—	298
23	Lovastatin	—	300
24	ly294002	—	11
25	Promethazine	—	121
26	protriptyline	—	296
27	streptonigrin	—	299
28	Sulfaphenazole	—	300
29	Triamcinolone	—	300
30	tyrphostin 1	—	1
31	tyrphostin ag 1478	—	4
32	Voriconazole	—	299
33	Cathelicidins Antimicrobial cationic peptides with	—	300
34	plumbagin [Supplementary Concept]	—	300
35	Ursolic Acid	—	300
36	Oleanolic Acid	—	300
37	pyrrolidine dithiocarbamate	—	275
38	vinblastine sulfate	—	81
39	alsterpaullone	—	12
40	Aurintricarboxylic Acid	—	184
41	Crizotinib	—	298
42	sp600125	—	117
43	glaucarubinone	—	10

About the IkBA variant leads to EDA-ID Pathway

The IkBA variant leads to EDA-ID pathway is catalogued in Reactome (ID: R-HSA-5603029) and involves 6 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, IKBKB, NFKB1, NFKB2, NFKBIA.