What compounds affect the Signaling by FGFR1 pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FGFR1 pathway (Reactome ID: R-HSA-5654736). These compounds target 10 genes within this pathway.

What genes are in the Signaling by FGFR1 pathway?

The Signaling by FGFR1 pathway involves 10 genes. Key genes include: BRAF, FGF22, FGFR1, GRB2, MAPK1, MAPK3, MKNK1, PIK3R1, PPP2CA, SRC.

Signaling by FGFR1

REACTOME PATHWAY

Reactome: R-HSA-565473610 genes43 compounds

The Signaling by FGFR1 pathway (Reactome ID: R-HSA-5654736) involves 10 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGF22 FGFR1 GRB2 MAPK1 MAPK3 MKNK1 PIK3R1 PPP2CA SRC

Compounds Affecting Signaling by FGFR1

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	alsterpaullone	—	12
3	tyrphostin ag 1478	—	4
4	kenpaullone	—	8
5	Dasatinib	—	299
6	Quercetin	—	300
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	sp600125	—	117
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	trametinib	—	296
12	withaferin	—	300
13	Afatinib	—	297
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Clotrimazole	—	296
16	fisetin	—	78
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	Resveratrol	—	298
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	Crizotinib	—	298
30	monorden	—	8
31	Niclosamide	—	299
32	pictilisib	—	25
33	Wortmannin	—	300
34	ly294002	—	11
35	alpelisib	—	227
36	Sirolimus	—	300
37	torin 1	—	10
38	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
39	hydroxyfasudil [Supplementary Concept]	—	11
40	Vemurafenib	—	298
41	Axitinib	—	298
42	Dactinomycin	—	297
43	Okadaic Acid	—	300

About the Signaling by FGFR1 Pathway

The Signaling by FGFR1 pathway is catalogued in Reactome (ID: R-HSA-5654736) and involves 10 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGF22, FGFR1, GRB2, MAPK1.