What compounds affect the Signaling by FGFR3 pathway?

44 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FGFR3 pathway (Reactome ID: R-HSA-5654741). These compounds target 10 genes within this pathway.

What genes are in the Signaling by FGFR3 pathway?

The Signaling by FGFR3 pathway involves 10 genes. Key genes include: BRAF, FGFR3, GALNT3, GRB2, MAPK1, MAPK3, MKNK1, PIK3R1, PPP2CA, SRC.

Signaling by FGFR3

REACTOME PATHWAY

Reactome: R-HSA-565474110 genes44 compounds

The Signaling by FGFR3 pathway (Reactome ID: R-HSA-5654741) involves 10 genes and is affected by 44 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGFR3 GALNT3 GRB2 MAPK1 MAPK3 MKNK1 PIK3R1 PPP2CA SRC

Compounds Affecting Signaling by FGFR3

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	tyrphostin ag 1478	—	4
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Dasatinib	—	299
6	Quercetin	—	300
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	sp600125	—	117
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	trametinib	—	296
12	withaferin	—	300
13	Afatinib	—	297
14	Crizotinib	—	298
15	Clotrimazole	—	296
16	fisetin	—	78
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	Resveratrol	—	298
28	Adenosine Monophosphate Adenine nucleotide containing	—	300
29	monorden	—	8
30	Niclosamide	—	299
31	pictilisib	—	25
32	Wortmannin	—	300
33	ly294002	—	11
34	alpelisib	—	227
35	Sirolimus	—	300
36	torin 1	—	10
37	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
38	hydroxyfasudil [Supplementary Concept]	—	11
39	Vemurafenib	—	298
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
41	Axitinib	—	298
42	Dactinomycin	—	297
43	Okadaic Acid	—	300
44	urolithin d	—	2

About the Signaling by FGFR3 Pathway

The Signaling by FGFR3 pathway is catalogued in Reactome (ID: R-HSA-5654741) and involves 10 genes. In the BiohacksAI corpus, 44 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGFR3, GALNT3, GRB2, MAPK1.