What compounds affect the Signaling by FGFR4 pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FGFR4 pathway (Reactome ID: R-HSA-5654743). These compounds target 9 genes within this pathway.

What genes are in the Signaling by FGFR4 pathway?

The Signaling by FGFR4 pathway involves 9 genes. Key genes include: BRAF, FGFR4, GRB2, MAPK1, MAPK3, MKNK1, PIK3R1, PPP2CA, SRC.

Signaling by FGFR4

REACTOME PATHWAY

Reactome: R-HSA-56547439 genes43 compounds

The Signaling by FGFR4 pathway (Reactome ID: R-HSA-5654743) involves 9 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRAF FGFR4 GRB2 MAPK1 MAPK3 MKNK1 PIK3R1 PPP2CA SRC

Compounds Affecting Signaling by FGFR4

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	tyrphostin ag 1478	—	4
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Quercetin	—	300
6	plumbagin [Supplementary Concept]	—	300
7	pd98059	—	7
8	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
9	trametinib	—	296
10	withaferin	—	300
11	Dasatinib	—	299
12	Afatinib	—	297
13	Clotrimazole	—	296
14	sp600125	—	117
15	fisetin	—	78
16	Progesterone	—	299
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Benzalkonium Compounds	—	299
19	Calcimycin	—	216
20	daph	—	2
21	Diphenhydramine	—	14
22	ha1004	—	4
23	Lithocholic Acid	—	300
24	Loratadine	—	296
25	trequinsin hydrochloride	—	1
26	Resveratrol	—	298
27	Adenosine Monophosphate Adenine nucleotide containing	—	300
28	Crizotinib	—	298
29	monorden	—	8
30	Niclosamide	—	299
31	pictilisib	—	25
32	Wortmannin	—	300
33	ly294002	—	11
34	alpelisib	—	227
35	Sirolimus	—	300
36	torin 1	—	10
37	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
38	hydroxyfasudil [Supplementary Concept]	—	11
39	Vemurafenib	—	298
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
41	Acrylamide	—	300
42	Dactinomycin	—	297
43	Okadaic Acid	—	300

About the Signaling by FGFR4 Pathway

The Signaling by FGFR4 pathway is catalogued in Reactome (ID: R-HSA-5654743) and involves 9 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRAF, FGFR4, GRB2, MAPK1, MAPK3.