What compounds affect the RHO GTPases Activate WASPs and WAVEs pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPases Activate WASPs and WAVEs pathway (Reactome ID: R-HSA-5663213). These compounds target 6 genes within this pathway.

What genes are in the RHO GTPases Activate WASPs and WAVEs pathway?

The RHO GTPases Activate WASPs and WAVEs pathway involves 6 genes. Key genes include: ABL1, BTK, CDC42, GRB2, MAPK1, MAPK3.

RHO GTPases Activate WASPs and WAVEs

REACTOME PATHWAY

Reactome: R-HSA-56632136 genes41 compounds

The RHO GTPases Activate WASPs and WAVEs pathway (Reactome ID: R-HSA-5663213) involves 6 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 BTK CDC42 GRB2 MAPK1 MAPK3

Compounds Affecting RHO GTPases Activate WASPs and WAVEs

#	Compound	Targets Hit	Studies
1	tyrphostin ag 1478	—	4
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Sorafenib	—	300
5	plumbagin [Supplementary Concept]	—	300
6	pd98059	—	7
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	trametinib	—	296
9	withaferin	—	300
10	Dasatinib	—	299
11	Crizotinib	—	298
12	Clotrimazole	—	296
13	sp600125	—	117
14	fisetin	—	78
15	Progesterone	—	299
16	2-Chloroadenosine 2-Chloroadenosine.	—	300
17	Benzalkonium Compounds	—	299
18	Calcimycin	—	216
19	daph	—	2
20	Diphenhydramine	—	14
21	ha1004	—	4
22	Lithocholic Acid	—	300
23	Loratadine	—	296
24	trequinsin hydrochloride	—	1
25	Axitinib	—	298
26	Afatinib	—	297
27	Avapritinib	—	246
28	Biotin	—	297
29	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
30	Imatinib Mesylate	—	300
31	triolimus [Supplementary Concept]	—	33
32	Genistein	—	300
33	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
34	pterostilbene	—	299
35	Quercetin	—	300
36	Adenosine Triphosphate	—	300
37	alpelisib	—	227
38	Nocodazole Nocodazole is	—	215
39	Oxytetracycline	—	300
40	casin	—	10
41	Dactinomycin	—	297

About the RHO GTPases Activate WASPs and WAVEs Pathway

The RHO GTPases Activate WASPs and WAVEs pathway is catalogued in Reactome (ID: R-HSA-5663213) and involves 6 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, BTK, CDC42, GRB2, MAPK1.