What compounds affect the RHO GTPases Activate Formins pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPases Activate Formins pathway (Reactome ID: R-HSA-5663220). These compounds target 28 genes within this pathway.

What genes are in the RHO GTPases Activate Formins pathway?

The RHO GTPases Activate Formins pathway involves 28 genes. Key genes include: AURKB, BIRC5, CDC42, PLK1, PPP1CC, PPP2CA, PPP2R5A, RHOC, SRC, TAOK1.

RHO GTPases Activate Formins

REACTOME PATHWAY

Reactome: R-HSA-566322028 genes52 compounds

The RHO GTPases Activate Formins pathway (Reactome ID: R-HSA-5663220) involves 28 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKB BIRC5 CDC42 PLK1 PPP1CC PPP2CA PPP2R5A RHOC SRC TAOK1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B XPO1

Compounds Affecting RHO GTPases Activate Formins

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Sorafenib	—	300
11	Quercetin	—	300
12	Crizotinib	—	298
13	Dasatinib	—	299
14	Okadaic Acid	—	300
15	sp600125	—	117
16	kenpaullone	—	8
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	fisetin	—	78
19	Axitinib	—	298
20	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Kaempferols	—	300
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	hydroxyfasudil [Supplementary Concept]	—	11
25	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
26	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
27	scutellarein	—	113
28	tamarixetin	—	26
29	ly294002	—	11
30	Wortmannin	—	300
31	Oleic Acid	—	112
32	Simvastatin	—	1,000
33	cefaclor	—	299
34	Disulfiram	—	297
35	Hexachlorophene	—	300
36	Lithocholic Acid	—	300
37	Nisoldipine	—	297
38	Oxyphenbutazone	—	300
39	Oxytetracycline	—	300
40	Resveratrol	—	298
41	tyrphostin ag 1478	—	4
42	Adenosine Monophosphate Adenine nucleotide containing	—	300
43	Afatinib	—	297
44	alsterpaullone	—	12
45	monorden	—	8
46	Niclosamide	—	299
47	plumbagin [Supplementary Concept]	—	300
48	oridonin	—	300
49	Buthionine Sulfoximine	—	300
50	Vitamin K 3	—	300

About the RHO GTPases Activate Formins Pathway

The RHO GTPases Activate Formins pathway is catalogued in Reactome (ID: R-HSA-5663220) and involves 28 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKB, BIRC5, CDC42, PLK1, PPP1CC.