What compounds affect the RHO GTPases Activate NADPH Oxidases pathway?

44 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPases Activate NADPH Oxidases pathway (Reactome ID: R-HSA-5668599). These compounds target 10 genes within this pathway.

What genes are in the RHO GTPases Activate NADPH Oxidases pathway?

The RHO GTPases Activate NADPH Oxidases pathway involves 10 genes. Key genes include: CYBB, MAPK1, MAPK11, MAPK14, MAPK3, NCF1, NOX1, PIK3C3, PIN1, PRKCZ.

RHO GTPases Activate NADPH Oxidases

REACTOME PATHWAY

Reactome: R-HSA-566859910 genes44 compounds

The RHO GTPases Activate NADPH Oxidases pathway (Reactome ID: R-HSA-5668599) involves 10 genes and is affected by 44 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYBB MAPK1 MAPK11 MAPK14 MAPK3 NCF1 NOX1 PIK3C3 PIN1 PRKCZ

Compounds Affecting RHO GTPases Activate NADPH Oxidases

#	Compound	Targets Hit	Studies
1	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
2	Sorafenib	—	300
3	withaferin	—	300
4	alsterpaullone	—	12
5	plumbagin [Supplementary Concept]	—	300
6	pd98059	—	7
7	tyrphostin ag 1478	—	4
8	kenpaullone	—	8
9	fisetin	—	78
10	trametinib	—	296
11	Dasatinib	—	299
12	Afatinib	—	297
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Anisomycin	—	247
15	celastrol	—	300
16	Clotrimazole	—	296
17	sp600125	—	117
18	Progesterone	—	299
19	2-Chloroadenosine 2-Chloroadenosine.	—	300
20	Benzalkonium Compounds	—	299
21	Calcimycin	—	216
22	daph	—	2
23	Diphenhydramine	—	14
24	ha1004	—	4
25	Lithocholic Acid	—	300
26	Loratadine	—	296
27	trequinsin hydrochloride	—	1
28	egcg	—	300
29	Quercetin	—	300
30	Celecoxib	—	295
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	chrysin	—	300
34	Naloxone	—	299
35	Arachidonic Acid	—	245
36	Sphingosine	—	300
37	Methylene Blue	—	200
38	indirubin	—	300
39	Loxapine	—	30
40	torin 1	—	10
41	pictilisib	—	25
42	Wortmannin	—	300
43	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
44	Aurintricarboxylic Acid	—	184

About the RHO GTPases Activate NADPH Oxidases Pathway

The RHO GTPases Activate NADPH Oxidases pathway is catalogued in Reactome (ID: R-HSA-5668599) and involves 10 genes. In the BiohacksAI corpus, 44 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYBB, MAPK1, MAPK11, MAPK14, MAPK3.