What compounds affect the RAF activation pathway?

35 compounds in the BiohacksAI corpus have documented interactions with genes in the RAF activation pathway (Reactome ID: R-HSA-5673000). These compounds target 14 genes within this pathway.

What genes are in the RAF activation pathway?

The RAF activation pathway involves 14 genes. Key genes include: ARAF, BRAF, CAMK2B, CAMK2D, JAK2, MAP2K1, MAP2K2, MARK3, PPP1CC, PPP2CA.

RAF activation

REACTOME PATHWAY

Reactome: R-HSA-567300014 genes35 compounds

The RAF activation pathway (Reactome ID: R-HSA-5673000) involves 14 genes and is affected by 35 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARAF BRAF CAMK2B CAMK2D JAK2 MAP2K1 MAP2K2 MARK3 PPP1CC PPP2CA PPP2R5A RAF1 SRC YWHAB

Compounds Affecting RAF activation

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Sorafenib	—	300
3	Vemurafenib	—	298
4	Quercetin	—	300
5	alsterpaullone	—	12
6	sp600125	—	117
7	Okadaic Acid	—	300
8	kenpaullone	—	8
9	trametinib	—	296
10	pd98059	—	7
11	Axitinib	—	298
12	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
13	Azauridine	—	300
14	Cladribine	—	297
15	Methylene Blue	—	200
16	2-Methoxyestradiol	—	300
17	Astemizole Antihistamine drug now withdrawn from	—	280
18	Azathioprine	—	300
19	Calcitriol	—	300
20	Camptothecin	—	300
21	Cytarabine	—	297
22	dihydrorotenone	—	13
23	Podophyllotoxin	—	14
24	streptonigrin	—	299
25	Trifluridine	—	295
26	Tripterygium	—	300
27	Resveratrol	—	298
28	tyrphostin ag 1478	—	4
29	Adenosine Monophosphate Adenine nucleotide containing	—	300
30	Afatinib	—	297
31	Crizotinib	—	298
32	monorden	—	8
33	Niclosamide	—	299
34	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
35	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300

About the RAF activation Pathway

The RAF activation pathway is catalogued in Reactome (ID: R-HSA-5673000) and involves 14 genes. In the BiohacksAI corpus, 35 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARAF, BRAF, CAMK2B, CAMK2D, JAK2.