What compounds affect the Regulation of necroptotic cell death pathway?

37 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of necroptotic cell death pathway (Reactome ID: R-HSA-5675482). These compounds target 4 genes within this pathway.

What genes are in the Regulation of necroptotic cell death pathway?

The Regulation of necroptotic cell death pathway involves 4 genes. Key genes include: CDC37, HSP90AA1, PRKN, RIPK3.

Regulation of necroptotic cell death

REACTOME PATHWAY

Reactome: R-HSA-56754824 genes37 compounds

The Regulation of necroptotic cell death pathway (Reactome ID: R-HSA-5675482) involves 4 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 HSP90AA1 PRKN RIPK3

Compounds Affecting Regulation of necroptotic cell death

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	Hexachlorophene	—	300
4	triolimus [Supplementary Concept]	—	33
5	monorden	—	8
6	gedunin	—	54
7	Novobiocin	—	300
8	caffeic acid	—	300
9	Masoprocol	—	300
10	Tetracycline	—	300
11	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Quercetin	—	300
14	2-Chloroadenosine 2-Chloroadenosine.	—	300
15	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
16	ag490	—	14
17	Calcimycin	—	216
18	Calcitriol	—	300
19	Ciclopirox	—	88
20	Clotrimazole	—	296
21	cycloheximide	—	300
22	deguelin [Supplementary Concept]	—	151
23	Disulfiram	—	297
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
32	kenpaullone	—	8
33	Genistein	—	300
34	amn082	—	29
35	Medroxyprogesterone Acetate	—	299
36	Nitrendipine	—	299
37	Vemurafenib	—	298

About the Regulation of necroptotic cell death Pathway

The Regulation of necroptotic cell death pathway is catalogued in Reactome (ID: R-HSA-5675482) and involves 4 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, HSP90AA1, PRKN, RIPK3.