What genes are in the MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway?

The MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway involves 6 genes. Key genes include: CHUK, CUL1, IKBKB, MAP2K1, MAP2K4, NFKB1.

MAP3K8 (TPL2)-dependent MAPK1/3 activation

Q: What compounds affect the MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway (Reactome ID: R-HSA-5684264). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56842646 genes47 compounds

The MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway (Reactome ID: R-HSA-5684264) involves 6 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHUK CUL1 IKBKB MAP2K1 MAP2K4 NFKB1

Compounds Affecting MAP3K8 (TPL2)-dependent MAPK1/3 activation

#	Compound	Targets Hit	Studies
1	Vemurafenib	—	298
2	chicoric acid	—	117
3	Quercetin	—	300
4	Resveratrol	—	298
5	Bortezomib	—	300
6	Podophyllotoxin	—	14
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Hydrocortisone	—	299
9	egcg	—	300
10	Kaempferols	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Rutin	—	300
13	Withania	—	500
14	Cerulenin	—	300
15	Chlorpropamide	—	300
16	daph	—	2
17	Disulfiram	—	297
18	Hexachlorophene	—	300
19	Hydrocortisone	—	298
20	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
21	Lovastatin	—	300
22	ly294002	—	11
23	Promethazine	—	121
24	protriptyline	—	296
25	streptonigrin	—	299
26	Sulfaphenazole	—	300
27	tamarixetin	—	26
28	Triamcinolone	—	300
29	Trifluridine	—	295
30	tyrphostin 1	—	1
31	tyrphostin ag 1478	—	4
32	withaferin	—	300
33	trametinib	—	296
34	pd98059	—	7
35	Dasatinib	—	299
36	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
37	Axitinib	—	298
38	Sorafenib	—	300
39	alsterpaullone	—	12
40	Aurintricarboxylic Acid	—	184
41	Crizotinib	—	298
42	sp600125	—	117
43	candesartan cilexetil [Supplementary Concept]	—	300
44	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
45	ninhydrin	—	300
46	Genistein	—	300
47	glaucarubinone	—	10

About the MAP3K8 (TPL2)-dependent MAPK1/3 activation Pathway

The MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway is catalogued in Reactome (ID: R-HSA-5684264) and involves 6 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHUK, CUL1, IKBKB, MAP2K1, MAP2K4.