What compounds affect the HDR through MMEJ (alt-NHEJ) pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the HDR through MMEJ (alt-NHEJ) pathway (Reactome ID: R-HSA-5685939). These compounds target 4 genes within this pathway.

What genes are in the HDR through MMEJ (alt-NHEJ) pathway?

The HDR through MMEJ (alt-NHEJ) pathway involves 4 genes. Key genes include: FEN1, PARP1, RAD52, RBBP8.

HDR through MMEJ (alt-NHEJ)

REACTOME PATHWAY

Reactome: R-HSA-56859394 genes49 compounds

The HDR through MMEJ (alt-NHEJ) pathway (Reactome ID: R-HSA-5685939) involves 4 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FEN1 PARP1 RAD52 RBBP8

Compounds Affecting HDR through MMEJ (alt-NHEJ)

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Methylene Blue	—	200
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Quercetin	—	300
6	Norepinephrine Precursor of epinephrine that is secreted by	—	298
7	Dequalinium	—	136
8	Diiodotyrosine	—	300
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	Epinephrine	—	299
11	Ethidium	—	300
12	Idarubicin	—	299
13	Levodopa	—	297
14	Methyldopa	—	297
15	piceatannol	—	300
16	Doxycycline	—	999
17	Carmine Coloring matter from	—	300
18	Cisplatin	—	300
19	Demeclocycline	—	297
20	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
21	Oxytetracycline	—	300
22	streptonigrin	—	299
23	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
24	Bortezomib	—	300
25	Camptothecin	—	300
26	Clofarabine	—	298
27	Daunorubicin	—	298
28	Demecolcine	—	246
29	Epirubicin	—	300
30	Gemcitabine	—	300
31	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
32	Irinotecan	—	298
33	Nocodazole Nocodazole is	—	215
34	Podophyllotoxin	—	14
35	Teniposide	—	299
36	Thapsigargin	—	300
37	Trabectedin	—	297
38	egcg	—	300
39	Perphenazine	—	297
40	Thioridazine	—	35
41	Chlorhexidine	—	299
42	Imatinib Mesylate	—	300
43	propionylpromazine hydrochloride	—	2
44	Catechin	—	300
45	Procaine	—	8
46	Sphingosine	—	300
47	Cefdinir	—	298
48	Fusaric Acid	—	300
49	Picloram	—	211

About the HDR through MMEJ (alt-NHEJ) Pathway

The HDR through MMEJ (alt-NHEJ) pathway is catalogued in Reactome (ID: R-HSA-5685939) and involves 4 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FEN1, PARP1, RAD52, RBBP8.