HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

Q: What compounds affect the HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) pathway?

256 compounds in the BiohacksAI corpus have documented interactions with genes in the HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) pathway (Reactome ID: R-HSA-5693567). These compounds target 21 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-569356721 genes256 compounds

The HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) pathway (Reactome ID: R-HSA-5693567) involves 21 genes and is affected by 256 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ATM BARD1 BLM BRCA1 CCNA1 CDK2 CHEK1 DNA2 MUS81 NSD2 PCNA POLH POLK RAD51 RAD52 RBBP8 SEM1 SIRT6 UBE2N WRN

Compounds Affecting HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Quercetin	—	300
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Chlorhexidine	—	299
5	kenpaullone	—	8
6	Aurintricarboxylic Acid	—	184
7	Methylene Blue	—	200
8	Methotrexate	—	289
9	Ethidium	—	300
10	Nocodazole Nocodazole is	—	215
11	sp600125	—	117
12	alsterpaullone	—	12
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Hexachlorophene	—	300
15	Idarubicin	—	299
16	Levodopa	—	297
17	Oxytetracycline	—	300
18	streptonigrin	—	299
19	Colchicine	—	300
20	cycloheximide	—	300
21	Melphalan	—	300
22	Podophyllotoxin	—	14
23	Trifluridine	—	295
24	vinblastine sulfate	—	81
25	Daunorubicin	—	298
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	Azacitidine	—	298
28	Azacitidine	—	300
29	Ciclopirox	—	88
30	Cytarabine	—	297
31	Demecolcine	—	246
32	Fluspirilene	—	74
33	Imatinib Mesylate	—	300
34	lidoflazine	—	278
35	Niclosamide	—	299
36	Perphenazine	—	297
37	piceatannol	—	300
38	alpha-Linolenic Acid	—	300
39	Masoprocol	—	300
40	Norepinephrine Precursor of epinephrine that is secreted by	—	298
41	Resveratrol	—	298
42	rafoxanide	—	172
43	Dasatinib	—	299
44	Axitinib	—	298
45	Bortezomib	—	300
46	Crizotinib	—	298
47	ag490	—	14
48	alpelisib	—	227
49	Sorafenib	—	300
50	trichostatic acid [Supplementary Concept] related to trichostatin	—	300

About the HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Pathway

The HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) pathway is catalogued in Reactome (ID: R-HSA-5693567) and involves 21 genes. In the BiohacksAI corpus, 256 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ATM, BARD1, BLM, BRCA1.