What compounds affect the DNA Damage Recognition in GG-NER pathway?

21 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Damage Recognition in GG-NER pathway (Reactome ID: R-HSA-5696394). These compounds target 3 genes within this pathway.

What genes are in the DNA Damage Recognition in GG-NER pathway?

The DNA Damage Recognition in GG-NER pathway involves 3 genes. Key genes include: COPS5, PARP1, RBX1.

DNA Damage Recognition in GG-NER

REACTOME PATHWAY

Reactome: R-HSA-56963943 genes21 compounds

The DNA Damage Recognition in GG-NER pathway (Reactome ID: R-HSA-5696394) involves 3 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

COPS5 PARP1 RBX1

Compounds Affecting DNA Damage Recognition in GG-NER

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
3	Bortezomib	—	300
4	Camptothecin	—	300
5	Clofarabine	—	298
6	Daunorubicin	—	298
7	Demecolcine	—	246
8	Epirubicin	—	300
9	Gemcitabine	—	300
10	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
11	Irinotecan	—	298
12	Nocodazole Nocodazole is	—	215
13	Podophyllotoxin	—	14
14	Teniposide	—	299
15	Thapsigargin	—	300
16	Trabectedin	—	297
17	DEAD-box RNA Helicases	—	169
18	Thioctic Acid	—	298
19	Sphingosine	—	300
20	Thioctic Acid	—	300
21	ninhydrin	—	300

About the DNA Damage Recognition in GG-NER Pathway

The DNA Damage Recognition in GG-NER pathway is catalogued in Reactome (ID: R-HSA-5696394) and involves 3 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include COPS5, PARP1, RBX1.