What compounds affect the Metabolism of fat-soluble vitamins pathway?

44 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of fat-soluble vitamins pathway (Reactome ID: R-HSA-6806667). These compounds target 9 genes within this pathway.

What genes are in the Metabolism of fat-soluble vitamins pathway?

The Metabolism of fat-soluble vitamins pathway involves 9 genes. Key genes include: AKR1B10, AKR1C1, AKR1C3, AKR1C4, PNLIP, RBP4, TTPA, TTR, VKORC1.

Metabolism of fat-soluble vitamins

REACTOME PATHWAY

Reactome: R-HSA-68066679 genes44 compounds

The Metabolism of fat-soluble vitamins pathway (Reactome ID: R-HSA-6806667) involves 9 genes and is affected by 44 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1B10 AKR1C1 AKR1C3 AKR1C4 PNLIP RBP4 TTPA TTR VKORC1

Compounds Affecting Metabolism of fat-soluble vitamins

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	egcg	—	300
4	Kaempferols	—	300
5	Vitamin	—	295
6	Quercetin	—	300
7	Medroxyprogesterone Acetate	—	299
8	Niflumic Acid	—	300
9	Thyroxine	—	994
10	pterostilbene	—	299
11	piceatannol	—	300
12	Thyroxine	—	300
13	Masoprocol	—	300
14	Genistein	—	300
15	Resveratrol	—	298
16	Rosmarinic Acid	—	300
17	Dextrothyroxine	—	134
18	Gemfibrozil	—	297
19	Triiodothyronine	—	300
20	Oleanolic Acid	—	300
21	Ursolic Acid	—	300
22	Chlorogenic Acid	—	300
23	caffeic acid	—	300
24	Pueraria	—	300
25	Rutin	—	300
26	Hesperidin	—	300
27	phlorhizin	—	224
28	Sulindac	—	297
29	alphitonin [Supplementary Concept] from	—	300
30	Pennisetum	—	291
31	Indomethacin	—	297
32	Naproxen	—	1,000
33	Berberine	—	300
34	Linoleic Acid	—	300
35	Bimatoprost	—	297
36	chrysin	—	300
37	Progesterone	—	299
38	Testosterone	—	299
39	Equilin	—	216
40	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
41	rafoxanide	—	172
42	Warfarin	—	1,000
43	Phenindione	—	300
44	Vitamin E	—	300

About the Metabolism of fat-soluble vitamins Pathway

The Metabolism of fat-soluble vitamins pathway is catalogued in Reactome (ID: R-HSA-6806667) and involves 9 genes. In the BiohacksAI corpus, 44 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1B10, AKR1C1, AKR1C3, AKR1C4, PNLIP.