What compounds affect the Signaling by MET pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by MET pathway (Reactome ID: R-HSA-6806834). These compounds target 9 genes within this pathway.

What genes are in the Signaling by MET pathway?

The Signaling by MET pathway involves 9 genes. Key genes include: GRB2, HPN, MET, PIK3R1, PTPN1, PTPN2, SRC, STAT3, USP8.

Signaling by MET

REACTOME PATHWAY

Reactome: R-HSA-68068349 genes46 compounds

The Signaling by MET pathway (Reactome ID: R-HSA-6806834) involves 9 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 HPN MET PIK3R1 PTPN1 PTPN2 SRC STAT3 USP8

Compounds Affecting Signaling by MET

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	celastrol	—	300
3	Crizotinib	—	298
4	Oleanolic Acid	—	300
5	Ursolic Acid	—	300
6	Lithocholic Acid	—	300
7	prunetin	—	35
8	Sorafenib	—	300
9	Afatinib	—	297
10	Niclosamide	—	299
11	Okadaic Acid	—	300
12	caffeic acid	—	300
13	Chlorogenic Acid	—	300
14	Methylene Blue	—	200
15	Oleic Acid	—	112
16	Mepentol [Supplementary Concept]	—	184
17	Evans Blue	—	300
18	Palmitic Acid	—	300
19	Suramin	—	300
20	vanadates	—	284
21	Dasatinib	—	299
22	Resveratrol	—	298
23	tyrphostin ag 1478	—	4
24	Adenosine Monophosphate Adenine nucleotide containing	—	300
25	alsterpaullone	—	12
26	kenpaullone	—	8
27	monorden	—	8
28	egcg	—	300
29	Axitinib	—	298
30	Adenosine Triphosphate	—	300
31	sp600125	—	117
32	pictilisib	—	25
33	Wortmannin	—	300
34	ly294002	—	11
35	alpelisib	—	227
36	Sirolimus	—	300
37	torin 1	—	10
38	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
39	Adapalene	—	296
40	alpha-Linolenic Acid	—	300
41	Anthralin	—	299
42	Gabexate	—	300
43	Meclizine	—	121
44	Fingolimod Hydrochloride	—	56
45	Celecoxib	—	295
46	Dactinomycin	—	297

About the Signaling by MET Pathway

The Signaling by MET pathway is catalogued in Reactome (ID: R-HSA-6806834) and involves 9 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, HPN, MET, PIK3R1, PTPN1.