What compounds affect the G1/S-Specific Transcription pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the G1/S-Specific Transcription pathway (Reactome ID: R-HSA-69205). These compounds target 8 genes within this pathway.

What genes are in the G1/S-Specific Transcription pathway?

The G1/S-Specific Transcription pathway involves 8 genes. Key genes include: CCNA1, CDK1, DHFR, HDAC1, PCNA, RRM2, TK1, TYMS.

G1/S-Specific Transcription

REACTOME PATHWAY

Reactome: R-HSA-692058 genes45 compounds

The G1/S-Specific Transcription pathway (Reactome ID: R-HSA-69205) involves 8 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNA1 CDK1 DHFR HDAC1 PCNA RRM2 TK1 TYMS

Compounds Affecting G1/S-Specific Transcription

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	sp600125	—	117
4	Pemetrexed	—	299
5	Methotrexate	—	289
6	Thymidine Monophosphate 5-Thymidylic acid.	—	202
7	indirubin	—	300
8	Clofibrate	—	299
9	Fenofibrate	—	297
10	Sertraline	—	1,000
11	Cinnarizine	—	299
12	Clotrimazole	—	296
13	Rotenone	—	300
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	chrysin	—	300
16	fisetin	—	78
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Quercetin	—	300
19	Sorafenib	—	300
20	Vorinostat	—	299
21	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
22	scriptaid	—	53
23	Valproic Acid	—	296
24	pictilisib	—	25
25	Butyric Acid	—	300
26	Ursolic Acid	—	300
27	Celecoxib	—	295
28	Daunorubicin	—	298
29	Bortezomib	—	300
30	Camptothecin	—	300
31	Fluorodeoxyuridylate 5-Fluoro-2'-deoxyuridylate.	—	102
32	Capecitabine	—	297
33	Cytarabine	—	297
34	Trifluridine	—	295
35	egcg	—	300
36	Folic Acid	—	296
37	Leucovorin	—	297
38	Sulfadiazine	—	298
39	Bromodeoxyuridine	—	300
40	Vidarabine	—	299
41	Clofarabine	—	298
42	Gemcitabine	—	300
43	Hydroxyurea	—	300
44	Oleanolic Acid	—	300
45	Triiodothyronine	—	300

About the G1/S-Specific Transcription Pathway

The G1/S-Specific Transcription pathway is catalogued in Reactome (ID: R-HSA-69205) and involves 8 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNA1, CDK1, DHFR, HDAC1, PCNA.