What compounds affect the Transcriptional Regulation by E2F6 pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional Regulation by E2F6 pathway (Reactome ID: R-HSA-8953750). These compounds target 10 genes within this pathway.

What genes are in the Transcriptional Regulation by E2F6 pathway?

The Transcriptional Regulation by E2F6 pathway involves 10 genes. Key genes include: BRCA1, CDC7, CHEK1, EED, EHMT1, EHMT2, EZH2, RAD51, RBBP8, RRM2.

Transcriptional Regulation by E2F6

REACTOME PATHWAY

Reactome: R-HSA-895375010 genes56 compounds

The Transcriptional Regulation by E2F6 pathway (Reactome ID: R-HSA-8953750) involves 10 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BRCA1 CDC7 CHEK1 EED EHMT1 EHMT2 EZH2 RAD51 RBBP8 RRM2

Compounds Affecting Transcriptional Regulation by E2F6

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Disulfiram	—	297
4	Glutathione	—	300
5	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
6	Dimethyl Sulfoxide	—	300
7	ninhydrin	—	300
8	kenpaullone	—	8
9	sp600125	—	117
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Resveratrol	—	298
12	Methotrexate	—	289
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Calcimycin	—	216
16	calycosin	—	300
17	Chlorhexidine	—	299
18	Ciclopirox	—	88
19	Colchicine	—	300
20	colchine	—	2
21	cycloheximide	—	300
22	Cytarabine	—	297
23	Demecolcine	—	246
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
25	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
26	dihydrorotenone	—	13
27	Fluspirilene	—	74
28	gedunin	—	54
29	Hexachlorophene	—	300
30	lidoflazine	—	278
31	Melphalan	—	300
32	Niclosamide	—	299
33	Nocodazole Nocodazole is	—	215
34	paxilline	—	42
35	Podophyllotoxin	—	14
36	rafoxanide	—	172
37	Semustine 4-Methyl derivative of LOMUSTINE; (CCNU).	—	97
38	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
39	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
40	Trifluridine	—	295
41	Tubercidin	—	300
42	vinblastine sulfate	—	81
43	Cyproheptadine	—	299
44	Gliotoxin	—	300
45	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
46	Quercetin	—	300
47	Biotin	—	297
48	Sorafenib	—	300
49	alsterpaullone	—	12
50	Cefdinir	—	298

About the Transcriptional Regulation by E2F6 Pathway

The Transcriptional Regulation by E2F6 pathway is catalogued in Reactome (ID: R-HSA-8953750) and involves 10 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BRCA1, CDC7, CHEK1, EED, EHMT1.