What compounds affect the Signaling by NTRK2 (TRKB) pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NTRK2 (TRKB) pathway (Reactome ID: R-HSA-9006115). These compounds target 8 genes within this pathway.

What genes are in the Signaling by NTRK2 (TRKB) pathway?

The Signaling by NTRK2 (TRKB) pathway involves 8 genes. Key genes include: CDK5, CDK5R1, FYN, GRB2, GRIN2B, NTRK2, PIK3R1, SRC.

Signaling by NTRK2 (TRKB)

REACTOME PATHWAY

Reactome: R-HSA-90061158 genes49 compounds

The Signaling by NTRK2 (TRKB) pathway (Reactome ID: R-HSA-9006115) involves 8 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK5 CDK5R1 FYN GRB2 GRIN2B NTRK2 PIK3R1 SRC

Compounds Affecting Signaling by NTRK2 (TRKB)

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	Sorafenib	—	300
3	alsterpaullone	—	12
4	egcg	—	300
5	Crizotinib	—	298
6	indirubin	—	300
7	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	fisetin	—	78
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	sp600125	—	117
13	Dasatinib	—	299
14	tyrphostin ag 1478	—	4
15	Quercetin	—	300
16	Glutamic Acid	—	297
17	Glutamic Acid	—	300
18	Glycine	—	300
19	eliprodil	—	33
20	pentamidine	—	299
21	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
22	Levorphanol	—	297
23	Aspartic Acid	—	300
24	cycloserine	—	298
25	D-Aspartic Acid	—	29
26	Dextrorphan Dextro form of levorphanol. It acts as	—	300
27	Ethidium	—	300
28	Dextrothyroxine	—	134
29	Dizocilpine Maleate	—	300
30	Ibotenic Acid	—	300
31	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
32	Spermine	—	300
33	hydroxyfasudil [Supplementary Concept]	—	11
34	Resveratrol	—	298
35	Adenosine Monophosphate Adenine nucleotide containing	—	300
36	Afatinib	—	297
37	monorden	—	8
38	Niclosamide	—	299
39	Rosmarinic Acid	—	300
40	Genistein	—	300
41	Acetic Acid Product of	—	300
42	pictilisib	—	25
43	Wortmannin	—	300
44	ly294002	—	11
45	alpelisib	—	227
46	Sirolimus	—	300
47	torin 1	—	10
48	tyrosol	—	300
49	Dactinomycin	—	297

About the Signaling by NTRK2 (TRKB) Pathway

The Signaling by NTRK2 (TRKB) pathway is catalogued in Reactome (ID: R-HSA-9006115) and involves 8 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, CDK5R1, FYN, GRB2, GRIN2B.