What compounds affect the Signaling by Erythropoietin pathway?

32 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Erythropoietin pathway (Reactome ID: R-HSA-9006335). These compounds target 9 genes within this pathway.

What genes are in the Signaling by Erythropoietin pathway?

The Signaling by Erythropoietin pathway involves 9 genes. Key genes include: GRB2, JAK2, LYN, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R5, STAT5A.

Signaling by Erythropoietin

REACTOME PATHWAY

Reactome: R-HSA-90063359 genes32 compounds

The Signaling by Erythropoietin pathway (Reactome ID: R-HSA-9006335) involves 9 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 JAK2 LYN PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R5 STAT5A

Compounds Affecting Signaling by Erythropoietin

#	Compound	Targets Hit	Studies
1	ly294002	—	11
2	pictilisib	—	25
3	Wortmannin	—	300
4	Sirolimus	—	300
5	alpelisib	—	227
6	torin 1	—	10
7	Dasatinib	—	299
8	Quercetin	—	300
9	Sorafenib	—	300
10	Azauridine	—	300
11	Cladribine	—	297
12	Methylene Blue	—	200
13	2-Methoxyestradiol	—	300
14	Astemizole Antihistamine drug now withdrawn from	—	280
15	Azathioprine	—	300
16	Calcitriol	—	300
17	Camptothecin	—	300
18	Cytarabine	—	297
19	dihydrorotenone	—	13
20	Podophyllotoxin	—	14
21	streptonigrin	—	299
22	Trifluridine	—	295
23	Tripterygium	—	300
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Ku 0063794 [Supplementary Concept]	—	7
26	tyrphostin ag 1478	—	4
27	alsterpaullone	—	12
28	Crizotinib	—	298
29	kenpaullone	—	8
30	sp600125	—	117
31	Resveratrol	—	298
32	Dactinomycin	—	297

About the Signaling by Erythropoietin Pathway

The Signaling by Erythropoietin pathway is catalogued in Reactome (ID: R-HSA-9006335) and involves 9 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, JAK2, LYN, PIK3CB, PIK3CD.