What compounds affect the Signaling by NOTCH3 pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NOTCH3 pathway (Reactome ID: R-HSA-9012852). These compounds target 14 genes within this pathway.

What genes are in the Signaling by NOTCH3 pathway?

The Signaling by NOTCH3 pathway involves 14 genes. Key genes include: ADAM10, APH1A, APH1B, CREBBP, EGFR, EP300, KAT2A, KAT2B, NCSTN, PSEN1.

Signaling by NOTCH3

REACTOME PATHWAY

Reactome: R-HSA-901285214 genes46 compounds

The Signaling by NOTCH3 pathway (Reactome ID: R-HSA-9012852) involves 14 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 APH1A APH1B CREBBP EGFR EP300 KAT2A KAT2B NCSTN PSEN1 PSEN2 PSENEN STAT1 TACC3

Compounds Affecting Signaling by NOTCH3

#	Compound	Targets Hit	Studies
1	Dihydroergocristine	—	187
2	Hexachlorophene	—	300
3	egcg	—	300
4	Oxytetracycline	—	300
5	streptonigrin	—	299
6	plumbagin [Supplementary Concept]	—	300
7	Aurintricarboxylic Acid	—	184
8	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
9	DEAD-box RNA Helicases	—	169
10	Thioctic Acid	—	298
11	Arachidonic Acid	—	245
12	Oleic Acid	—	112
13	alpha-Linolenic Acid	—	300
14	candesartan cilexetil [Supplementary Concept]	—	300
15	Cisplatin	—	300
16	diallyl trisulfide	—	246
17	Estramustine	—	300
18	gamma-Linolenic Acid	—	300
19	Iodoacetamide	—	300
20	Lithocholic Acid	—	300
21	rafoxanide	—	172
22	Ritonavir	—	298
23	Thioctic Acid	—	300
24	Trazodone	—	297
25	Aminoimidazole Carboxamide	—	121
26	Histamine	—	300
27	cefaclor	—	299
28	Cefdinir	—	298
29	Thioridazine	—	35
30	Budesonide	—	1,000
31	Methylene Blue	—	200
32	Flurandrenolone	—	65
33	Dasatinib	—	299
34	Afatinib	—	297
35	tyrphostin ag 1478	—	4
36	ag490	—	14
37	tyrphostin 1	—	1
38	Bisphenol A-Glycidyl Methacrylate	—	197
39	Kaempferols	—	300
40	Progesterone	—	299
41	Papaverine	—	299
42	Colchicine	—	300
43	Etazolate	—	66
44	Nocodazole Nocodazole is	—	215
45	11-hydroxypalmatine [Supplementary Concept]	—	238
46	np1	—	81

About the Signaling by NOTCH3 Pathway

The Signaling by NOTCH3 pathway is catalogued in Reactome (ID: R-HSA-9012852) and involves 14 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, APH1A, APH1B, CREBBP, EGFR.